收稿日期: 2023-06-15
网络出版日期: 2023-11-22
基金资助
山东省医药卫生科技发展计划项目(2019WS331)
Progress of SphK1/S1P in the biological behavior of tumor malignancy
Received date: 2023-06-15
Online published: 2023-11-22
张文路 , 徐春燕 . SphK1/S1P在肿瘤恶性生物学行为中的研究进展[J]. 实用医学杂志, 2023 , 39(19) : 2551 -2555 . DOI: 10.3969/j.issn.1006-5725.2023.19.024
Sphingophosphokinase 1 （SphK1） is a regulator of sphingomolipin metabolites that catalyzes the conversion of sphingosine-1-phosphate （S1P） to sphingosine-1-phosphate. SphK1/S1P is overexpressed in a variety of cancers. This paper reviewed the role and mechanism of SphK1/S1P in malignant biological behaviors of tumors， such as tumor cell proliferation， epithelial mesenchymal transformation， acquisition of stem-like properties， remodeling of tumor microenvironment， regulation of tumor immune function， and promotion of distant metastasis of tumor cells. It is suggested that SphK1/S1P plays a key role in multiple malignant biological behaviors of tumors.
| 1 | ZHAO Y， LING Z， HAO Y， et al. MiR-124 acts as a tumor suppressor by inhibiting the expression of sphingosine kinase 1 and its downstream signaling in head and neck squamous cell carcinoma［J］. Oncotarget， 2017， 8（15）： 25005-25020. |
| 2 | HII L W， CHUNG F F， MAI C W， et al. Sphingosine Kinase 1 Signaling in Breast Cancer： A Potential Target to Tackle Breast Cancer Stem Cells［J］. Front Mol Biosci， 2021， 8： 748470. |
| 3 | MA Y， XING X， KONG R， et al. SphK1 promotes development of non?small cell lung cancer through activation of STAT3［J］. Int J Mol Med， 2021， 47（1）： 374-386. |
| 4 | 曹宇华，殷舞，吕艳茹. 敲低鞘氨醇激酶-1对非小细胞肺癌细胞增殖及线粒体凋亡途径的影响及机制［J］. 生理学报，2021，73（6）：893-900. |
| 5 | LI P H， WU J X， ZHENG J N， et al. A sphingosine kinase-1 inhibitor， SKI-II， induces growth inhibition and apoptosis in human gastric cancer cells［J］. Asian Pac J Cancer Prev， 2014， 15（23）： 10381-10385. |
| 6 | LI W， LI J， WANG Y， et al. Sphingosine kinase 1 is a potential therapeutic target for nasopharyngeal carcinoma［J］. Oncotarget， 2016， 7（49）： 80586-80598. |
| 7 | SUKOCHEVA O A. Expansion of Sphingosine Kinase and Sphingosine-1-Phosphate Receptor Function in Normal and Cancer Cells： From Membrane Restructuring to Mediation of Estrogen Signaling and Stem Cell Programming［J］. Int J Mol Sci， 2018， 19（2）：420. |
| 8 | TAN S S， KHIN L W， WONG L， et al. Sphingosine kinase 1 promotes malignant progression in colon cancer and independently predicts survival of patients with colon cancer by competing risk approach in South asian population［J］. Clin Transl Gastroenterol， 2014， 5（2）： e51. |
| 9 | LONG J， YAO Z， SUI Y， et al. SphK1 Promotes Cancer Progression through Activating JAK/STAT Pathway and Up-Regulating S1PR1 Expression in Colon Cancer Cells［J］. Anticancer Agents Med Chem， 2022， 22（2）： 254-260. |
| 10 | LI Q， LI X， YANG X， et al. Long Intergenic Nonprotein Coding RNA 173 Inhibits Tumor Growth and Promotes Apoptosis by Repressing Sphingosine Kinase 1 Protein Expression in Pancreatic Cancer［J］. DNA Cell Biol， 2021， 40（6）： 757-775. |
| 11 | LU P H， CHEN M B， LIU Y Y， et al. Identification of sphingosine kinase 1 （SphK1） as a primary target of icaritin in hepatocellular carcinoma cells［J］. Oncotarget， 2017， 8（14）： 22800-22810. |
| 12 | POWELL J A， LEWIS A C， ZHU W， et al. Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia［J］. Blood， 2017， 129（6）： 771-782. |
| 13 | TAMASHIRO P M， FURUYA H， SHIMIZU Y， et al. Sphingosine kinase 1 mediates head & neck squamous cell carcinoma invasion through sphingosine 1-phosphate receptor 1［J］. Cancer Cell Int， 2014， 14（1）： 76. |
| 14 | BONICA J， CLARKE C J， OBEID L M， et al. Upregulation of sphingosine kinase 1 in response to doxorubicin generates an angiogenic response via stabilization of Snail［J］. FASEB J， 2023， 37（3）： e22787. |
| 15 | XU C Y， LIU S Q， QIN M B， et al. SphK1 modulates cell migration and EMT-related marker expression by regulating the expression of p-FAK in colorectal cancer cells［J］. Int J Mol Med， 2017， 39（5）： 1277-1284. |
| 16 | WU J N， LIN L， LUO S B， et al. SphK1-driven autophagy potentiates focal adhesion paxillin-mediated metastasis in colorectal cancer［J］. Cancer Med， 2021， 10（17）： 6010-6021. |
| 17 | LIU H， MA Y， HE H W， et al. SPHK1 （sphingosine kinase 1） induces epithelial-mesenchymal transition by promoting the autophagy-linked lysosomal degradation of CDH1/E-cadherin in hepatoma cells［J］. Autophagy， 2017， 13（5）： 900-913. |
| 18 | ZENG Y， YAO X， CHEN L， et al. Sphingosine-1-phosphate induced epithelial-mesenchymal transition of hepatocellular carcinoma via an MMP-7/ syndecan-1/TGF-beta autocrine loop［J］. Oncotarget， 2016， 7（39）： 63324-63337. |
| 19 | KAWAHARA S， OTSUJI Y， NAKAMURA M， et al. Sphingosine kinase 1 plays a role in the upregulation of CD44 expression through extracellular signal-regulated kinase signaling in human colon cancer cells［J］. Anticancer Drugs， 2013， 24（5）： 473-483. |
| 20 | PATEL D S， AHMAD F， SNEINEH M ABU， et al. The Importance of Sphingosine Kinase in Breast Cancer： A Potential for Breast Cancer Management［J］. Cureus， 2021， 13（2）： e13413. |
| 21 | BEACH J A， ASPURIA P J， CHEON D J， et al. Sphingosine kinase 1 is required for TGF-beta mediated fibroblastto- myofibroblast differentiation in ovarian cancer［J］. Oncotarget， 2016， 7（4）： 4167-4182. |
| 22 | SATYANANDA V， OSHI M， TOKUMARU Y， et al. Sphingosine 1-phosphate （S1P） produced by sphingosine kinase 1 （SphK1） and exported via ABCC1 is related to hepatocellular carcinoma （HCC） progression［J］. Am J Cancer Res， 2021， 11（9）： 4394-4407. |
| 23 | TSUCHIDA J， NAGAHASHI M， NAKAJIMA M， et al. Sphingosine Kinase 1 is Associated With Immune Cell-Related Gene Expressions in Human Breast Cancer［J］. J Surg Res， 2020， 256： 645-656. |
| 24 | LI H， XING X， ZHANG X， et al. Effects of triptolide on the sphingosine kinase-Sphingosine-1-phosphate signaling pathway in colitis-associated colon cancer［J］.Int Immunopharmacol， 2020， 88： 106892. |
| 25 | LI L， WANG D， XIN S， et al. Sphingosine Kinase 1 Acts as a Hypoxia-Upregulated Oncogene to Regulate Cell Invasion and Resistance to NK Cell Killing in Bladder Carcinoma Cells［J］. Ann Clin Lab Sci， 2022， 52（5）： 763-771. |
| 26 | ACHARYA S， YAO J， LI P， et al. Sphingosine Kinase 1 Signaling Promotes Metastasis of Triple-Negative Breast Cancer［J］. Cancer Res， 2019， 79（16）： 4211-4226. |
| 27 | NAGAHASHI M， YAMADA A， KATSUTA E， et al. Targeting the SphK1/S1P/S1PR1 Axis That Links Obesity， Chronic Inflammation， and Breast Cancer Metastasis［J］. Cancer Res， 2018， 78（7）： 1713-1725. |
| 28 | STAYROOK K R， MACK J K， CERABONA D， et al. TGFbeta-Mediated induction of SphK1 as a potential determinant in human MDA-MB-231 breast cancer cell bone metastasis［J］. Bonekey Rep， 2015， 4： 719. |
| 29 | YIN S， MIAO Z， TAN Y， et al. SPHK1-induced autophagy in peritoneal mesothelial cell enhances gastric cancer peritoneal dissemination［J］. Cancer Med， 2019， 8（4）： 1731-1743. |
| 30 | ELASBALI A M， Al-SOUD W A， ALHASSAN H H， et al. Discovering Gummadiol and Isoarboreol as potential inhibitors of sphingosine kinase 1： virtual screening and MD simulation studies［J］. J Biomol Struct Dyn， 2023， 1-9. |
/
| 〈 |
|
〉 |