目的 应用二维斑点追踪成像（2D⁃STI）技术评估紫杉醇联合卡铂对卵巢癌患者左心室收缩 功能及运动同步性的影响。方法 卵巢癌术后患者 30 例，紫杉醇联合卡铂治疗，于化疗前、3 周期、6 周期 检查，正常人 30 例作为对照。常规超声检查后，分层应变技术检测：左心室整体及 3 层心肌的纵向与圆周 应变（GLS、GLS⁃endo、GLS⁃mid、GLS⁃epi、GCS、GCS⁃endo、GCS⁃mid、GCS⁃epi），整体达峰时间标准差（Tssl⁃SD、 Tssc⁃SD）和达峰时间最大差值（Tssl⁃Dif、Tssc⁃Dif）及延迟指数（LSDI、CSDI），比较各组参数的差异。应用 ROC曲线评价各参数监测心脏毒性的临床价值。比较各参数与药物累积剂量的相关性。结果 与对照组 相比，化疗前组无明显差异，而化疗 3 及 6 周期组常规参数（LVEDV、LVEF、e′）降低，E/e′值增大；化疗 3 及 6 周期组 GLS、GLS⁃endo、GLS⁃mid、GCS、GCS⁃endo、GCS⁃mid 显著减低，具有降低趋势，GLS⁃epi 与 GCS⁃epi 在 化疗 6 周期降低；化疗 3 周期组 Tssl⁃SD 和 LSDI 出现延迟，而化疗 6 周期组仅 Tssl⁃SD 更明显（P < 0.05）。 ROC 曲线显示：GLS⁃endo 的 AUC（0.922）及特异度最高（86.67%），GLS 敏感度最高（90.00%）。GLS⁃endo 与 药物剂量呈负相关（r = -0.732，P < 0.01）。结论 2D⁃STI 技术能早期评估紫杉醇联合卡铂对卵巢癌患者

Objective To evaluate the effect of paclitaxel combined with carboplatin on left ventricular systolic function and motor synchrony in patients with ovarian cancer using two ⁃ dimensional speckle tracking imaging（2D⁃STI）technique. Methods A total of 30 patients with ovarian cancer were collected after surgery and received paclitaxel combined with carboplatin，and they were examined before chemotherapy，3⁃cycle，and 6⁃cycle， and 30 healthy subjects were selected forthe control group. After routine ultrasound examination，the layered strain technique was used to detect the longitudinal and circumferential strains of the whole left ventricle . The three layers of myocardium（GLS，GLS⁃endo，GLS⁃mid，GLS⁃epi，GCS，GCS⁃endo，CS⁃mid，CS⁃epi），the standard deviation of the time to peak（Tssl⁃SD，Tssc⁃SD）and the maximum difference（Tssl⁃dif，Tssc⁃dif）and the delay index （LSDI，CSDI）were obtained. The difference of parameters in each groupwere compared，and the ROC curve was used to evaluate the clinical value of various parameters in monitoring cardiac toxicity. The association between the parameters and the cumulative dose was analyzed. Results No significant difference was found between the pre⁃ chemotherapy group and the control group，while the conventional parameters（LVEDV，LVEF，e′）of the 3⁃cycle chemotherapy group and the 6⁃cycle chemotherapy group decreased，and the E/e′ value increased. The GLS，GLS⁃ endo，GLS⁃mid，GCS，GCS⁃endo，group were significantly reduced（P < 0.05），with a decreasing trend. At the same time，GLS⁃epi and GCS⁃epi decreased during 6⁃cycle of chemotherapy. The delay of Tssl ⁃ SD and LSDI in the 3⁃cycle chemotherapy group， while the delay of Tssl⁃SD in the 6⁃cycle chemotherapy group was more obvious. The ROC curve showed that AUC （0.922）and specificity（90.00%）of GLS⁃endo were the highest，the GLS sensitivity was the highest（86.67%）， GLS⁃endo was negatively correlated with drug dose（r = -0.732，P < 0.01）. Conclusion 2D⁃STI technique should be used in the early assessment of paclitaxel combined with carboplatin on left ventricular systolic function and