收稿日期: 2023-03-24
网络出版日期: 2023-10-10
基金资助
国家自然科学基金资助项目(82160371);江西省卫生健康委科技计划(202210595)
Research progress of mild therapeutic hypothermia in neonatal moderate to severe hypoxic-ischemic encephalopathy
Received date: 2023-03-24
Online published: 2023-10-10
李曼君 , 张静 , 余树春 , 邓伟 . 治疗性浅低温在新生儿中重度缺氧缺血性脑病中的研究进展[J]. 实用医学杂志, 2023 , 39(18) : 2411 -2415 . DOI: 10.3969/j.issn.1006-5725.2023.18.022
Neonatal hypoxic-ischemic encephalopathy refers to brain damage caused by perinatal asphyxia， which can cause death and permanent neurological impairment in severe cases. Therapeutic hypothermia reduces death or disability in term and near-term infants with moderate to severe hypoxic-ischaemic encephalopathy. The latest studies have further refined the key parameters of hypothermia， including the timing， depth of cooling， duration， subsequent rate of rewarming， and prevention of fever during delivery and resuscitation. The key to improving neurodevelopmental outcomes is early postnatal diagnosis and initiation of hypothermia. This article will review the research progress of mild therapeutic hypothermia in neonatal hypoxic-ischemic encephalopathy， and introduce commonly used hypothermia induction methods， clinical challenges and future development directions.
| 1 | THAYYIL S， MONTALDO P， KRISHNAN V， et al. Whole-Body Hypothermia， Cerebral Magnetic Resonance Biomarkers， and Outcomes in Neonates With Moderate or Severe Hypoxic-Ischemic Encephalopathy Born at Tertiary Care Centers vs Other Facilities： A Nested Study Within a Randomized Clinical Trial［J］. JAMA Netw Open， 2023，6（5）： e2312152. |
| 2 | 李修晶，赵芳萍，刘东海，等. 促红细胞生成素联合亚低温治疗中重度新生儿缺氧缺血性脑病疗效及治疗期间安全性分析［J］. 实用医学杂志， 2021，37（1）： 57-62. |
| 3 | FEI Q， WANG D， YUAN T. Comparison of Different Adjuvant Therapies for Hypothermia in Neonates with Hypoxic-Ischemic Encephalopathy： A Systematic Review and Network Meta-Analysis［J］. Indian J Pediatr， 2023. doi：10.1007/S12098-023-04563-3 |
| 4 | FASCE J， NOVOA J M， TOSO P， et al. ［Current status of Therapeutic Hypothermia in Hypoxic-Ischemic Encephalopathy］［J］. Andes Pediatr， 2021，92（6）： 831-837. |
| 5 | GALA A， KUMAR H， SEDANI S， et al. Alterations in the Stool Microbiome in Newborns Undergoing Mild Therapeutic Hypothermia after Hypoxic-Ischemic Encephalopathy［J］. Dev Neurosci， 2022，44（4/5）： 373-383. |
| 6 | MICHNIEWICZ B， SZPECHT D， SOWINSKA A， et al. Biomarkers in newborns with hypoxic-ischemic encephalopathy treated with therapeutic hypothermia［J］. Childs Nerv Syst， 2020，36（12）： 2981-2988. |
| 7 | FLIBOTTE J， LAPTOOK A R， SHANKARAN S， et al. Blanket temperature during therapeutic hypothermia and outcomes in hypoxic ischemic encephalopathy［J］. J Perinatol， 2022，42（3）： 348-353. |
| 8 | DAVIES A， WASSINK G， BENNET L， et al. Can we further optimize therapeutic hypothermia for hypoxic-ischemic encephalopathy？［J］. Neural Regen Res， 2019，14（10）： 1678-1683. |
| 9 | RISTOVSKA S， STOMNAROSKA O， DANILOVSKI D. Hypoxic Ischemic Encephalopathy （HIE） in Term and Preterm Infants［J］. Pril （Makedon Akad Nauk Umet Odd Med Nauki）， 2022，43（1）： 77-84. |
| 10 | 于子芮，刘春阳，方心，等. 宫内窘迫新生儿发生缺氧缺血性脑病的危险因素分析［J］. 中国现代医学杂志，2019，29（14）：69-72. |
| 11 | SALAMAH A， EL A D， ELSHEIKH M， et al. Citicoline in hypoxic ischemic encephalopathy in neonates： a randomized controlled trial［J］. Ital J Pediatr， 2023，49（1）： 55. |
| 12 | NATARAJAN N， BENEDETTI G， PEREZ F A， et al. Association Between Early EEG Background and Outcomes in Infants With Mild HIE Undergoing Therapeutic Hypothermia［J］. Pediatr Neurol， 2022，134： 52-58. |
| 13 | SABIR H， MAES E， ZWEYER M， et al. Comparing the efficacy in reducing brain injury of different neuroprotective agents following neonatal hypoxia-ischemia in newborn rats： a multi-drug randomized controlled screening trial［J］. Sci Rep， 2023，13（1）： 9467. |
| 14 | BRUNETS N， BRUNETS V， BOKINIEC R. Echocardiographic and ultrasound evaluation of haemodynamic parameters in hypoxic neonates treated with hypothermia： Study protocol［J］. Front Pediatr， 2023，11： 1122738. |
| 15 | 中华医学会儿科学分会新生儿学组，中华儿科杂志编辑委员会. 亚低温治疗新生儿缺氧缺血性脑病专家共识（2022）［J］. 中华儿科杂志， 2022，60（10）： 983-989. |
| 16 | SAW C L， RAKSHASBHUVANKAR A， RAO S， et al. Current Practice of Therapeutic Hypothermia for Mild Hypoxic Ischemic Encephalopathy［J］. J Child Neurol， 2019，34（7）： 402-409. |
| 17 | NAVEED M， BONDI D S， SHAH P A. Dexmedetomidine Versus Fentanyl for Neonates With Hypoxic Ischemic Encephalopathy Undergoing Therapeutic Hypothermia［J］. J Pediatr Pharmacol Ther， 2022，27（4）： 352-357. |
| 18 | LUCKE A M， SHETTY A N， HAGAN J L， et al. Early proton magnetic resonance spectroscopy during and after therapeutic hypothermia in perinatal hypoxic-ischemic encephalopathy［J］. Pediatr Radiol， 2019，49（7）： 941-950. |
| 19 | HU Y， CHEN F， XIANG X， et al. Early versus delayed enteral nutrition for neonatal hypoxic-ischemic encephalopathy undergoing therapeutic hypothermia： a randomized controlled trial［J］. Ital J Pediatr， 2022，48（1）： 146. |
| 20 | ELLIOTT M， BURNSED J， HEINAN K， et al. Effect of dexmedetomidine on heart rate in neonates with hypoxic ischemic encephalopathy undergoing therapeutic hypothermia［J］. J Neonatal Perinatal Med， 2022，15（1）： 47-54. |
| 21 | LAPTOOK A R， SHANKARAN S， TYSON J E， et al. Effect of Therapeutic Hypothermia Initiated After 6 Hours of Age on Death or Disability Among Newborns With Hypoxic-Ischemic Encephalopathy： A Randomized Clinical Trial［J］. JAMA， 2017，318（16）： 1550-1560. |
| 22 | KINOSHITA A N， MAGALHAES M， RODRIGUES D P， et al. Effectiveness of reaching and maintaining therapeutic hypothermia target temperature using low-cost devices in newborns with hypoxic-ischemic encephalopathy［J］. Anat Rec （Hoboken）， 2021，304（6）： 1217-1223. |
| 23 | ABATE B B， BIMEREW M， GEBREMICHAEL B， et al. Effects of therapeutic hypothermia on death among asphyxiated neonates with hypoxic-ischemic encephalopathy： A systematic review and meta-analysis of randomized control trials［J］. PLoS One， 2021，16（2）： e247229. |
| 24 | ZENOBI C， WISNOWSKI J L， TAMRAZI B， et al. Effects of Tissue Temperature and Injury on ADC during Therapeutic Hypothermia in Newborn Hypoxic-Ischemic Encephalopathy［J］. AJNR Am J Neuroradiol， 2022，43（3）： 462-467. |
| 25 | SAKHUJA P， MORE K， TING J Y， et al. Gastrointestinal hemodynamic changes during therapeutic hypothermia and after rewarming in neonatal hypoxic-Ischemic encephalopathy［J］. Pediatr Neonatol， 2019，60（6）： 669-675. |
| 26 | 邓伟， 胡玉龙， 牛江峰， 等. 治疗性浅低温在缺血性脑卒中的研究进展［J］. 实用医学杂志， 2019，35（20）： 3119-3123. |
| 27 | SMITH H N， HUGHES D C. Improving the Timeliness and Safety of Therapeutic Hypothermia for Hypoxic-Ischemic Encephalopathy［J］. Pediatr Qual Saf， 2020，5（3）： e283. |
| 28 | BACKE P， BRUSCHETTINI M， BLOMQVIST Y T， et al. Interventions for the management of Pain and Sedation in Newborns undergoing Therapeutic hypothermia for hypoxic-ischemic encephalopathy （IPSNUT）： protocol of a systematic review［J］. Syst Rev， 2022，11（1）： 101. |
| 29 | WALAS W， WILINSKA M， BEKIESINSKA-FIGATOWSKA M， et al. Methods for assessing the severity of perinatal asphyxia and early prognostic tools in neonates with hypoxic-ischemic encephalopathy treated with therapeutic hypothermia［J］. Adv Clin Exp Med， 2020，29（8）： 1011-1016. |
| 30 | PRESSLER R M， CILIO M R， MIZRAHI E M， et al. The ILAE classification of seizures and the epilepsies： Modification for seizures in the neonate. Position paper by the ILAE Task Force on Neonatal Seizures［J］. Epilepsia， 2021，62（3）： 615-628. |
| 31 | MOLLOY E J， BEARER C. Neonatal encephalopathy versus Hypoxic-Ischemic Encephalopathy［J］. Pediatr Res， 2018，84（5）： 574. |
| 32 | RUSS J B， SIMMONS R， GLASS H C. Neonatal Encephalopathy： Beyond Hypoxic-Ischemic Encephalopathy［J］. Neoreviews， 2021，22（3）： e148-e162. |
| 33 | KUBO H， SHIMONO R， NAKAMURA S， et al. Hypoxic-Ischemic Encephalopathy-Associated Liver Fatty Degeneration and the Effects of Therapeutic Hypothermia in Newborn Piglets［J］. Neonatology， 2017，111（3）： 203-210. |
| 34 | BENEDETTI G M， VARTANIAN R J， MCCAFFERY H， et al. Early Electroencephalogram Background Could Guide Tailored Duration of Monitoring for Neonatal Encephalopathy Treated with Therapeutic Hypothermia［J］. J Pediatr， 2020，221： 81-87. |
| 35 | LEMYRE B， CHAU V. Hypothermia for newborns with hypoxic-ischemic encephalopathy［J］. Paediatr Child Health， 2018，23（4）： 285-291. |
| 36 | PARMENTIER C， DE VRIES L S， GROENENDAAL F. Magnetic Resonance Imaging in （Near-）Term Infants with Hypoxic-Ischemic Encephalopathy［J］. Diagnostics （Basel）， 2022，12（3）：645. |
| 37 | EL F M， PIJLS N. Cardioprotection， Autoretroperfusion， and Therapeutic Hypothermia［J］. JACC Basic Transl Sci， 2020，5（3）： 279-281. |
/
| 〈 |
|
〉 |