Objective To explore the effect of renal attenin capsule combined with levkanetine on RBP4 and BMP⁃7 in patients with stage 3 to 4 chronic renal disease. Methods A total of 100 patients with chronic kidney disease hospitalized in our hospital from January 2019 to January 2021 were randomly selected and equally divided into control groups and observation group by the digital table method. After 14 d treatment，the two groups were compared in terms of the levels of interleukin⁃17（IL⁃17），hypersensitive C⁃reactive protein（hs⁃CRP），interferon （INFγ），retinol⁃binding protein 4（RBP4），bone morphogenesis protein⁃7（BMP⁃7），serum cystatin⁃C（Cys⁃C）， blood urea nitrogen（BUN），blood creatinine（SCr），maldialaldehyde（MDA），glutathione⁃peroxidase（GSH⁃Px）， superoxide dismutase（SOD），and 24 h urinary protein quantification（24 h UTP）. Results After treatment，the levels of IL⁃17，s⁃CRP and IFNγ，MDA，RBP4，Cys⁃C，24 h UTP ，BUN and SCr of the observation group were significantly lowered（P < 0.05），and the levels of GSH ⁃Px，SOD and BMP ⁃7 were significantly elevated（P < 0.05），as compared with the control group. Conclusion Renal attenin capsule combined with levkanitine kidney disease can enhance slow recovery of kidney function of patients with stage 3 to 4 chronic renal disease by reducing the oxidative stress and renal microinflammation.