目的 探讨磷酸钙混合富血小板血浆（platelet⁃rich plasma，PRP）置入重建股骨头在早期股骨头坏死（osteonecrosis of the femoral head，ONFH）治疗中的潜在友好性。方法 将河南省中医院关节外科自2016 年6 月至2018 年1 月收治的早期ONFH 患者108 例，依照随机数字表法将患者分为联合组与对照组，联合组52 例（髋），对照组56 例（髋）。对照组进行坏死骨刮除、β⁃磷酸钙颗粒填充打压、β⁃磷酸钙柱状陶瓷棒置入；联合组则将β⁃磷酸钙颗粒、柱状β⁃磷酸钙陶瓷棒浸润PRP 进行填充打压置入。对两组患者进行术后不同时间位点VAS、Harris 评分及影像学测评、量化指标对比。结果 术后24个月多个时间位点对比，联合组置入物矿化、新生骨爬行生长替代明显优于对照组（P＜0.05）；联合组VAS 及Harris 亦优于对照组（F = 30.12、17.88，P＜0.05）。结论 微创坏死骨刮除、磷酸钙置入对早期ONFH 可修复性是客观的，微创保髋术联合PRP，可加速新生骨爬行生长矿化、促进磷酸钙置入物与自身宿主骨的融合。

Objective The research tried to investigate the reliability of platelet⁃rich plasma compositesβ⁃alcium phosphate for the treatment of early Osteonecrosis of the Femoral Head. Methods 108 patients of earlyOsteonecrosis of the Femoral Head（unilateral lesion）were randomly divided into compound group（52 cases）andcontrol group（56 cases）. The control group was treated with osteonecrosis bone scraping，biomaterials β⁃alciumphosphate particles filling and pressing as well as β⁃alcium phosphate columnar ceramic rod implantation. Thecomposite group mixed biomaterials β ⁃alcium phosphate particles to match platelet⁃ich plasma filling andcompression and columnar calcium phosphate ceramic rod implantation. The VAS and Harris scores，imaging evalu⁃ation and quantitative indexes were compared between the two groups. Results Compared with multiple time sitesin 24 months after operation，the implant mineralization and new bone crawling growth replacement in the compos⁃ite group were significantly better than those in the control group（P < 0.05）. The VAS and Harris in the compositegroup were also better than those in the control group（F = 30.12，17.88，P＜0.05）. Conclusion Platelet⁃richplasma composites β⁃alcium phosphate have a reliable advantage in the treatment of early Osteonecrosis of theFemoral Head，which could accelerate the growth and mineralization of new bone crawling，promote the fusion ofcalcium phosphate implants with their own host bone and facilitate functional recovery.