关键词:

干细胞, 移植, 缺血性脑卒中, 纳米颗粒, 基因工程联合细胞

Abstract:

Ischemic stroke is a disease with a high mortality and disability rate. According to most reports at home and abroad，its cause is related to cerebrovascular occlusion，and new treatment is urgently needed for clinical intervention. Stem cells can secrete neurotrophic factors to replace damaged neurons；they can play a neuro⁃ protective effect by inhibiting intracranial and extracranial inflammation and anti ⁃apoptosis. They can also release nutrients and growth factors that enhance endogenous repair mechanisms to protect and repair nerves. Therefore， the use of stem cell transplantation to treat ischemic stroke is expected to become a new option. This article summa⁃ rizes the mechanism of stem cells transplantation in the treatment of ischemic stroke and its clinical application， the role of nanomaterials in stem cell therapy，and post⁃transplantation tracking and monitoring of stem cell imag⁃ ing methods for stem cell treatment of ischemic stroke. 

Key words:

stem cell, transplant, ischemic stroke, nanoparticles, genetic engineering united cell