实用医学杂志 ›› 2021, Vol. 37 ›› Issue (7): 835-838.doi: 10.3969/j.issn.1006⁃5725.2021.07.002

• 新型冠状病毒肺炎专栏 • 上一篇    下一篇

新型冠状病毒肺炎:高凝、血栓形成及抗凝

王同生, 苏秀丽, 高鹏飞, 褚旭, 邱家勇, 毛毅敏    

  1. 河南科技大学第一附属医院呼吸与危重症医学科,河南科技大学临床医学院(河南洛阳 471003)

  • 出版日期:2021-04-10 发布日期:2021-04-10
  • 基金资助:
    洛阳市科技局疫情防控应急科研攻关项目(编号:2020YZ20)

COVID ⁃19:hypercoagulability,thrombosis and anticoagulation

WANG Tongsheng,SU Xiuli,GAO Peng⁃ fei,CHU Xu,QIU Jiayong,MAO Yimin   

  1. Department of Respiratory Diseases,the First Affiliated Hospital,and Col⁃ lege of Clinical Medicine of He′nan University of Science and Technology,Luoyang 471003,China

  • Online:2021-04-10 Published:2021-04-10

摘要:

新型冠状病毒肺炎(COVID⁃19)是由新型冠状病毒(SARS⁃CoV⁃2)引起的,其特征是炎症反应过度表达。SARS⁃CoV⁃2可触发COVID⁃19 患者产生高凝和血栓形成,50%重症患者合并有高凝状态。高达40% COVID⁃19患者合并有深静脉血栓形成(deep veinthrombosis,DVT)和肺栓塞(pulmonary thrombo⁃embolism,PTE),推荐应用低分子肝素(LMWH)预防性抗凝治疗。LMWH 除了抗凝作用外,还具有非抗凝作用,如能减少白细胞介素⁃6(IL⁃6)释放以及抑制淋巴细胞增加,可以延缓或阻断炎症“细胞因子风暴”。

关键词:

新型冠状病毒, 新型冠状病毒肺炎, 高凝, 血栓形成, 抗凝

Abstract:

Coronavirus Disease 2019(COVID⁃19)is caused by the new coronavirus SARS⁃CoV⁃2 and is characterized by an exaggerated inflammatory response. SARS ⁃CoV ⁃2 can trigger coagulopathy and thrombosis in patients with covid ⁃ 19. In severe cases,50% of the patients had coagulopathy. Up to 40% of patients still have deep vein thrombosis(DVT)and pulmonary embolism(PTE). Low molecular weight heparin(LMWH)is recom⁃ mended as prophylactic anticoagulant therapy,Besides the Anticoagulant effect of LMWH,nonanticoagulant prop⁃ erties such as the reduction in interleukin 6 release and increasing the number of Limba cells,it can delay or block the inflammatory“cytokine storm”

Key words:

SARS?CoV?2, COVID?19, hypercoagulability, thrombosis, anticoagulation