骨髓间充质干细胞来源细胞外囊泡治疗股骨头骨坏死的研究进展

doi:10.3969/j.issn.1006-5725.2025.23.001

摘要/Abstract

摘要：

股骨头坏死（osteonecrosis of the femoral head，ONFH）是一种致残性骨科疾病，以进行性股骨头塌陷伴骨小梁、关节软骨结构破坏为病理特征，导致髋关节疼痛及进行性功能障碍。骨髓间充质干细胞来源细胞外囊泡（BMSC-derived exosomes，BMSC-EVs）在组织修复和再生方面有良好的前景，免疫原性和致瘤性较低，影响成骨、成血管和免疫调节。本文综述了BMSC-EVs在ONFH中的治疗效果及其潜在机制，为ONFH的治疗提供理论依据。

关键词: 股骨头坏死, 骨髓间充质干细胞, 细胞外囊泡, 骨修复

Abstract:

Osteonecrosis of the femoral head （ONFH） is a disabling orthopedic disease， pathologically characterized by progressive collapse of the femoral head accompanied by destruction of the trabecular and articular cartilage structures， leading to hip joint pain and progressive functional impairment. Bone marrow mesenchymal stem cell-derived extracellular vesicles （BMSC-EVs） show great promise in tissue repair and regeneration， with low immunogenicity and tumorigenicity， and play roles in osteogenesis， angiogenesis， and immunomodulation. This review summarizes the therapeutic effects and underlying mechanisms of BMSC-EVs in ONFH， providing a theoretical basis for its treatment.

Key words: femoral head necrosis, bone marrow mesenchymal stem cells, extracellular vesicles, bone repair

中图分类号:

R274

李爱强,赵宁,张旭升,柳海平. 骨髓间充质干细胞来源细胞外囊泡治疗股骨头骨坏死的研究进展[J]. 实用医学杂志, 2025, 41(23): 3631-3637.

Aiqiang LI,Ning ZHAO,Xusheng ZHANG,Haiping. LIU. Research progress on the treatment of femoral skull necrosis by extracellular vesicles from bone marrow mesenchymal stem cells[J]. The Journal of Practical Medicine, 2025, 41(23): 3631-3637.

图/表 1

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