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Abstract:

Objective This study observed the analgesic effect of dexmedetomidine（DEX）combined with ropivacaine for postoperative analgesia after modified radical mastectomy. Methods The patients were randomly divided into group T1，group T2 and group C. Group T1 was treated with 0.375% ropivacaine 20 mL plus Dex 1 μg/kg ，group T2 with 0.375% ropivacaine 20 mL plus Dex 1.5 μg/kg and Group C with 0.375% ropivacaine 20 mL. The onset time and the number of sensory block segments after anesthesia，the use of narcotic drugs during operation，postoperative visual analogue score，postoperative morphine use，blood glucose，high⁃sensitivity C⁃reac⁃ tive protein and complications were recorded. Results The onset time of block in group T was faster than that in group C（P < 0.05）；the number of sensory block segments in group T was more than that in group C（P < 0.05）； the amount of anesthetic drugs used in group T was less than that in group C（P < 0.05）；the VAS score in group T was lower than that in group C（P < 0.05）；the dosage of morphine in group T was less than that in group C（P < 0.05）； the changes of blood glucose and high ⁃sensitivity C ⁃ reactive protein in group T were lower than those in group C （P < 0.05）；the incidence of complications in group T1 was the lowest（P < 0.05）. Conclusion Thoracic para⁃ spinal block with DEX and ropivacaine for radical mastectomy could enhance the effect of postoperative analgesia； thoracic paraspinal block with Dex 1ug / kg had better analgesic effect and fewer adverse reactions.

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