关键词:

妊娠期, 血小板减少, 凝血功能, 产后出血, 静脉血栓栓塞症

Abstract:

Objective To investigate the dynamic changes of coagulation function in gestational thrombo⁃ cytopenia（GT）patients. Methods A total of 55 GT patients who had registered in our hospital from October 2019 to June 2022 and had regular obstetric check⁃ups were enrolled into observation group，and 60 normal preg⁃ nant woman were selected as the control group. The level of PT，APTT，TT，FIB and DD were detected by automatic coagulation analyzer. PLT，PCT，MPV and PDW were measured by automatic blood cell analyzer. T test was used to compare the differences of coagulation function between GT patients and normal pregnant women in the third trimester of pregnancy，and the dynamic changes of coagulation function before and after delivery in GT patients. Results Prenatal PLT and PCT were lower，while MPV and PDW higher in the observation group than those in the control group，showing statistical significance（t = -18.184，-17.277，3.083，and 3.671 respectively，P < 0.05）. Prenatal PT in the observation group was significantly shorter；FIB significantly lower，while DD significantly higher than those in the control group and the differences were statistically significant（t = -3.560，-3.331 and 3.412 respectively，P < 0.05）. There was no significantdifference between prenatal APTT and TT in the two groups （P > 0.05）. After delivery，PLT in GT patients were significantly elevated，indicating statistical significance（P < 0.05）；there was no significant differenceinMPV，PDWand PCT in GT patients before and after delivery（P > 0.05）. PT and APTT in GT patients after delivery were prolonged，while DD increased and the differences were statistically significant（P < 0.05）；there was no significant difference in TT and FIB in GT patients before and after delivery（P > 0.05）. Conclusion Prolonged PT and APTT，and elevated DD and PLT in postpartum GT patients suggest that postpartum hemorrhage and venous thromboembolism（VTE）are still possiblein GTpatients. Therefore，dynamic evaluation of coagulation function in GT patients provides reference for the effective prevention of postpartum hemorrhage and VTE.

Key words:

pregnancy, thrombocytopenia, coagulation function, postpartum hemorrhage, VTE