不同类型重度子痫前期患者脐动脉血HSP70表达与胎儿出生状况及短期预后的关系

doi:10.3969/j.issn.1006⁃5725.2021.16.010

实用医学杂志 ›› 2021, Vol. 37 ›› Issue (16): 2084-2088.doi: 10.3969/j.issn.1006⁃5725.2021.16.010

不同类型重度子痫前期患者脐动脉血HSP70表达与胎儿出生状况及短期预后的关系

彭永保1，张丽琼2，刘淮1

1 南昌大学附属妇幼保健院（南昌 330006）；2 南昌大学研究生院麻醉学系（南昌 330006）

出版日期:2021-08-25 发布日期:2021-08-25
通讯作者: 刘淮 E⁃mail：lh8830@126.com
基金资助:
国家自然科学基金项目（编号：81460238）；江西省重点研发计划项目（编号：20181BBG78055）

Relationship between the expression of HSP70 in umbilical artery blood and fetal birth status and short ⁃ term prognosis in patients with different types of severe preeclampsia

PENG Yongbao*，ZHANG Liqiong， LIU Huai.

Maternal and Child Health Hospital Affiliated to Nanchang University，Nanchang 330006，China

Online:2021-08-25 Published:2021-08-25
Contact: LIU Huai E⁃mail：lh8830@126.com

摘要/Abstract

摘要：

目的探讨不同类型重度子痫前期患者脐动脉血 HSP70 表达与胎儿出生状况及短期预后的关系。方法选取剖宫产分娩且 35 周 ≤ 孕龄 ≤ 36 周的重度子痫前期孕妇 60 例为研究对象，早发型和晚发型各 30 例，选择同期单纯早产孕妇 30 例为对照组。记录各组胎儿娩出后的出生状况、短期预后及转归，检测母体血清、脐动脉血中 HSP70 水平。结果低出生体重儿发生率为早发型组（63.33%）> 晚发型组（48.33%）>对照组（29.67%），组间比较差异均有统计学意义（均 P < 0.05）；早发型组新生儿出生 1 min 和 5 min 的 Apgar 评分均低于晚发型组和对照组（均 P < 0.05），三组母体循环及脐带血 HSP70 水平均为早发型组>晚发型组>对照组（均 P < 0.05），三组新生儿转入 NICU 的比例、NICU 住院时长及总住院时长均为早发型组>晚发型组>对照组（均 P < 0.05）。结论重度子痫前期患者脐动脉血中 HSP70 表达水平与疾病严重程度及胎儿出生状况密切相关，其可能是反映重度子痫前期患者胎儿发育状况的良好指标。

关键词:

重度子痫前期, 热休克蛋白70, 脐动脉血, 出生状况

Abstract:

Objective To investigate the relationship between the expression of HSP70 in umbilical artery blood and fetal birth status and short ⁃ term prognosis in patients with different types of severe preeclampsia. Methods The research subjects were 60 pregnant women with severe preeclampsia who underwent cesarean section，including 30 early⁃onset and 30 late⁃onset patients，and 30 cases of simple premature women were selected as the control group. The birth status，short⁃term prognosis were recorded. ELISA was used to detect HSP70 levels in serum and umbilical artery blood，and the correlation was analyzed. Results The incidence of low birth weight infants was early⁃onset group（63.33%）> late⁃onset group（48.33%）> control group（29.67%）（P < 0.05），the Apgar scores of the early⁃onset group at 1 min and 5 min after birth were lower than those of the late⁃onset group and the control group（P < 0.05）. The levels of HSP70 in maternal circulation and umbilical cord blood were early⁃ onset group > late ⁃onset group > control group（P < 0.05）. The proportion of newborns transferred to NICU，the length of stay in NICU and the total length of stay in hospital were early⁃onset group > late⁃onset group > control group（P < 0.05）. Conclusion In patients with severe preeclampsia，the expression of HSP70 in umbilical artery blood is closely related to the severity of disease and fetal birth status，suggesting that it may be a good indicator of fetal development status.

Key words: severe preeclampsia, , heat shock protein 70, , umbilical artery blood, , birth status

彭永保, 张丽琼, 刘淮.

不同类型重度子痫前期患者脐动脉血HSP70表达与胎儿出生状况及短期预后的关系 [J]. 实用医学杂志, 2021, 37(16): 2084-2088.

PENG Yongbao, ZHANG Liqiong, LIU Huai. .

Relationship between the expression of HSP70 in umbilical artery blood and fetal birth status and short ⁃ term prognosis in patients with different types of severe preeclampsia [J]. The Journal of Practical Medicine, 2021, 37(16): 2084-2088.

不同类型重度子痫前期患者脐动脉血HSP70表达与胎儿出生状况及短期预后的关系

Relationship between the expression of HSP70 in umbilical artery blood and fetal birth status and short ⁃ term prognosis in patients with different types of severe preeclampsia

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