Objective To observe the effect of combined hypoglycemic regimen of insulin digu and liraglu⁃ tide on type 2 diabetes patients with poorly controlled blood glucose. Methods From January to December 2021， 60 type 2 diabetes patients with poor blood glucose control who were admitted to the Endocrinology Department of Wuhan Central Hospital were selected for a prospective observational study. The patients were divided into the con⁃ trol group and the test group in equal number with the random number table method. The control group was treated with insulin glargine combined with insulin glulisine for 12 weeks，and the test group with insulin degludec com⁃ bined with liraglutide for 12 weeks as well. Analysis of variance and t⁃test statistical methods were used to compare the glycosylated hemoglobin（HbA1c），fasting blood glucose（FPG），fasting serum C ⁃ peptide（FCP），2⁃ hour postprandial serum C⁃peptide（2hPCP），insulin resistance index（ HOMA⁃IR），body mass index（BMI）levels， daily dosage of basal insulin，and clinical effect of lowering blood sugar between the two groups. Results After 12 weeks treatment，the levels of HbA1c and FPG in both groups were lower than those before treatment（P < 0.01）， but there was no significant difference between the two groups（P > 0.05）. The levels of FCP and 2hPCP in the test group were higher than those in the control group. The level of HOMA⁃IR in the test group was lower than that in the control group（t = 8.757，23.760，6.998，P < 0.01）. The daily dose of basal insulin and the BMI in the test group were lower than those in the control group as well，and the total effective rate in the test group was signifi⁃ cantly higher compared with the control group（χ2 = 15.37，P < 0.01）. Conclusion The therapy with Degu insulin and lilalutide combined is effective and stable in the treatment of type 2 diabetes patients with poor blood glucose control. It has few adverse reactions and other benefits as well besides glucose reduction.