关键词:

高毒力肺炎克雷伯菌, 碳青霉烯耐药, 质粒, 毒力

Abstract:

Klebsiella pneumoniae is a kind of clinical common opportunistic pathogen. In recent years，more and moreclinical strains integrating hypervirulence and carbapenem resistance，i.e.，carbapenem ⁃ resistant hypervirulent K. pneumoniae（CR⁃hvKP）have been isolated and leads to untreatable invasive infections and even fa⁃tal transmission. In this paper，the epidemiological characteristics and drug resistance mechanism were summa⁃rized. At present ST11⁃CR⁃HvKP has the highest prevalence in China. CR⁃hvkp mainly transfers virulence and resistance genes in Gram ⁃negative pathogensby mobile genetic elements such as plasmids，integrative conjugative elements（ICEs），integrons，insertion sequences（is）and transposons. At the same time，the environmental coloni⁃zation of CR⁃hvkp and the resulting risk of infection and transmission undoubtedly pose great challenges to the prevention and control of infection.The in⁃depth study on the clinical characteristics and drug resistance mechanis⁃mof carbapenem⁃resistant hypervirulent Klebsiella pneumoniae（CR⁃hvkp）will help us to find feasible methods to eradicate or prevent the further evolution and spread of the strain. 

Key words:

hypervirulent klebsiella pneumonia, carbapenem resistance, plasmids, virulence