实用医学杂志 ›› 2021, Vol. 37 ›› Issue (19): 2464-2467.doi: 10.3969/j.issn.1006⁃5725.2021.19.006

• 临床研究 • 上一篇    下一篇

子宫内膜异位症性不孕患者自然妊娠及IVF/ICSI后早期自然流产率的回顾性研究

周敏 郭春   

  1. 电子科技大学附属医院·四川省人民医院妇产科生殖中心(成都610072)

  • 出版日期:2021-10-10 发布日期:2021-10-10
  • 通讯作者: 郭春 E⁃mail:chunguo11@hotmail.com
  • 基金资助:
    国家自然科学基金青年基金资助项目(编号:81801423)

Early miscarriage rate before and after IVF/ICSI in infertile patients with endometriosis:A retrospective study

ZHOU Min,GUO Chun.   

  1. Center for Reproductive Medicine,Department of Obstetrics and Gynecology,Univer⁃ sity of Electronic Science and Technology of China,Sichuan Provincial People′s Hospital,Chengdu 610072,China

  • Online:2021-10-10 Published:2021-10-10
  • Contact: GUO Chun E⁃mail:chunguo11@hotmail.com

摘要:

目的 研究子宫内膜异位症(EMs)性不孕患者行辅助生殖助孕的早期自然流产发生率。 方法 分析比较 2016 1 月至 2021 3 月在我院行体外受精(in vitro fertilization,IVF)或单精子卵细胞注 射(intracytoplasmic sperm injection,ICSI)助孕的EMs不孕患者(n = 198)和输卵管因素不孕患者(n = 179)的妊 娠结局。结果 EMs组自然妊娠的早期流产率显著高于对照组(25.60% vs. 14.55%,P < 0.05)。辅助生殖助 孕后,EMs组受精率(69.22%)及优胚率(51.91%)均低于对照组(79.53%、59.19%,P < 0.05)。EMs患者行新鲜 或冷冻胚胎移植后早期流产率分别为24.39%、21.31%,均高于对照组(7.14%、4.69%,P < 0.05)。结论 EMs 不孕患者辅助助孕受精率和优胚率降低且流产率升高,提示EMs可通过影响胚胎质量等因素导致不孕不育。

关键词:

内异症, 体外受精, 早期自然流产

Abstract:

Objective To study the early miscarriage rate of in vitro fertilization in infertile patients with endometriosis(EMs). Methods Pregnancy outcomes of 198 infertile patients with EMs and 179 infertility patients with tubal problems treated with IVF or ICSI in our hospital from January 2016 to March 2021 were retro⁃ spectively investigated. Results The early miscarriage rate of natural pregnancy in the endometriosis group was significantly higher than that in the control group(25.60% vs. 14.55%,P < 0.05). After IVF or ICSI,the fertiliza⁃ tion rate and high⁃quality embryo rate in the endometriosis group were significantly lower than those in the control group,respectively(69.22% vs. 79.53%;51.91% vs. 59.19%,P < 0.05). The early miscarriage rate after the im⁃ plantation of fresh or frozen embryos in the EMS patients was significantly higher than that in the control group respectively(24.39% vs. 7.14%,21.31% vs. 4.69%,P < 0.05). Conclusion The fertilization rate and high⁃quality embryo rate are lower and the early miscarriage rate is higher in the EMS patients,indicating that endometriosis may lead to infertility by impairing the embryo quality and other factors. 

Key words:

endometriosis, in vitro fertilization, miscarriage