肿瘤浸润淋巴细胞在不同分子亚型乳腺癌新辅助化疗中的作用

doi:10.3969/j.issn.1006⁃5725.2021.17.015

实用医学杂志 ›› 2021, Vol. 37 ›› Issue (17): 2243-2251.doi: 10.3969/j.issn.1006⁃5725.2021.17.015

肿瘤浸润淋巴细胞在不同分子亚型乳腺癌新辅助化疗中的作用

谢芳1 马骖1 吴玲玲2 单宏杰1 马强1 黄赞1

安徽医科大学附属宿州医院，宿州市立医院1 肿瘤外科，2 病理科（安徽宿州 234000）

出版日期:2021-09-10 发布日期:2021-09-10
基金资助:
安徽医科大学校科研基金（编号：2019xky100）

Predictive value of tumor⁃infiltrating lymphocytes in patients with different subtypes of breast cancer treat⁃ ed with neoadjuvant chemotherapy

XIE Fang*，MA Can，WU Lingling，SHAN Hongjie，MA Qiang，HUANG Zan.#br#

Department of Surgical Oncology，Suzhou Hospital Affiliated to Anhui Medical University，Suzhou Municipal Hospital，Suzhou 234000，China

Online:2021-09-10 Published:2021-09-10

摘要/Abstract

摘要：

目的探讨肿瘤浸润淋巴细胞（tumor infiltrating lymphocytes，TILs）对不同分子亚型乳腺癌患者新辅助化疗疗效的预测作用。方法收集 2019 年 7 月至 2020 年 7 月期间于我院行新辅助化疗后并行手术的 56 例女性乳腺癌患者的临床病理资料。高倍镜下计算化疗前穿刺组织中的 TILs 比例，分为低、中、高组，术后病理评估大体标本肿瘤组织的化疗反应并进行统计学分析。结果新辅助化疗总有效率为 76.8%（43/56），TILs 高比例组的新辅助化疗总体有效率高于低比例组（P < 0.05），三阴性乳腺癌（TNBC）患者的 TILs 比例要高于其他两个分子亚型（P < 0.05）。多因素分析显示新辅助化疗疗效与 TILs 比例相关，与年龄、ER、PR、HER⁃2 及 Ki⁃67 均无相关性。结论 TILs 比例可能是乳腺癌新辅助化疗反应的独立预测因子，高TILs 比例预示着疗效更佳，这在三阴性乳腺癌患者中更为明显。

关键词:

肿瘤浸润淋巴细胞, 乳腺肿瘤, 新辅助化疗, 化疗反应

Abstract:

Objective To analyze the predictive value of tumor infiltrating lymphocytes（TILs）in patients with different subtypes of breast cancer treated with neoadjuvant chemotherapy. Methods The clinicopathological data of 56 female patients who underwent neoadjuvant chemotherapy in our hospital from July 2019 to July 2020 were analyzed. The proportion of TILs in the punctured tissue before chemotherapy was calculated and divided into low，medium，and high groups. Postoperative pathological assessment of the chemotherapy response of gross tumor tissues and statistical analysis were performed. Results The total effective rate of neoadjuvant chemotherapy was 76.8%（43/56），the effective rate of neoadjuvant chemotherapy in high TILs proportion group was higher than that in the low TILs proportion group（P < 0.05），and the TILs rate of triple negative breast cancer patients was signifi⁃ cantly higher than that of Luminal type and HER⁃2 positive breast cancer（P < 0.05）. Multivariate analysis showed that the efficacy of neoadjuvant chemotherapy was only related to TILs ratio，but not to age，HR state，HER ⁃2 state and Ki ⁃67 index. Conclusions TILs proportion is an independent predictor for the efficacy of neoadjuvant chemotherapy in breast cancer. A high proportion of TILs indicates a better therapeutic effect，which is more obvi⁃ ous in patients with triple⁃negative breast cancer.

Key words:

tumor infiltrating lymphocytes, breast tumor, neoadjuvant chemotherapy, response to chemotherapy

谢芳马骖吴玲玲单宏杰马强黄赞 .

肿瘤浸润淋巴细胞在不同分子亚型乳腺癌新辅助化疗中的作用 [J]. 实用医学杂志, 2021, 37(17): 2243-2251.

XIE Fang, MA Can, WU Lingling, SHAN Hongjie, MA Qiang, HUANG Zan..

Predictive value of tumor⁃infiltrating lymphocytes in patients with different subtypes of breast cancer treat⁃ ed with neoadjuvant chemotherapy [J]. The Journal of Practical Medicine, 2021, 37(17): 2243-2251.

肿瘤浸润淋巴细胞在不同分子亚型乳腺癌新辅助化疗中的作用

Predictive value of tumor⁃infiltrating lymphocytes in patients with different subtypes of breast cancer treat⁃ ed with neoadjuvant chemotherapy

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