基于光学相干断层成像的血流储备分数在冠心病诊疗中的应用研究进展

doi:10.3969/j.issn.1006-5725.2024.20.023

摘要/Abstract

摘要：

冠心病的患病率逐年上升，死亡率居于首位，早预防、早诊断、早治疗，减少病死率十分重要。冠脉造影是诊断冠心病金标准，在临床应用广泛，但并不能准确地反映冠脉的病变程度。血流储备分数（blood flow reserve fraction， FFR）是目前评价冠状动脉狭窄功能的参考标准。但其是一项有创的检查，操作复杂、价格昂贵、血管扩张药物相关副作用多、可重复性差等诸多因素限制了其在临床上的广泛应用。近年来与影像学相关的无创血流储备分数越来越多的被应用到临床中。定量血流分数（quantitative blood flow fraction， QFR）、基于光学相干断层成像的血流储备分数（OCT-based optical flow ratio， OFR）成为了研究的热点。OFR作为一种较新的技术，受到了越来越多的关注。该文将对上述技术的基本原理、临床价值和研究进展进行描述。

关键词: 血流储备分数, 定量血流分数, 基于光学相干断层成像的血流储备分数, 无创血流储备分数

Abstract:

The incidence of coronary heart disease is increasing year by year， with the mortality rate ranking first. Early prevention， diagnosis， and treatment are crucial to reduce the mortality rate. Coronary angiography is the gold standard for diagnosing coronary heart disease and is widely used in clinical practice， but it cannot accurately reflect the degree of coronary artery disease. Blood flow reserve fraction （FFR） is currently the reference standard for evaluating coronary artery stenosis function. However， it is an invasive examination that is limited in clinical application due to factors such as complex operation， high cost， multiple side effects related to vasodilators， and poor reproducibility. In recent years， non-invasive blood flow reserve scores related to imaging have been increasingly applied in clinical practice. Quantitative flow fraction （QFR） and optical coherence tomography based flow reserve fraction （OCT based optical flow ratio OFR） have become research hotspots. OFR， as a relatively new technology， has received increasing attention. Therefore， this article will describe the basic principles， clinical value， and research progress of the above-mentioned technologies.

Key words: blood flow reserve score, quantitative blood flow fraction, blood flow reserve score based on optical coherence tomography, non-invasive blood flow reserve score

中图分类号:

R543.5

陆再丽,李超中,夏洁,吴雨竹,赵然尊. 基于光学相干断层成像的血流储备分数在冠心病诊疗中的应用研究进展[J]. 实用医学杂志, 2024, 40(20): 2960-2964.

Zaili LU,Chaozhong LI,Jie XIA,Yuzhu WU,Ranzun ZHAO. The application value and research progress of blood flow reserve fraction based on optical coherence tomography in coronary heart disease[J]. The Journal of Practical Medicine, 2024, 40(20): 2960-2964.

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