实用医学杂志 ›› 2022, Vol. 38 ›› Issue (2): 234-238.doi: 10.3969/j.issn.1006⁃5725.2022.02.020

• 中医药现代化 • 上一篇    下一篇

宫颈高危型人乳头状瘤病毒感染中医证型、 体质分布及相关危险因素的研究

周方芳1 桂涛1，2 黄美华1，2 甘霖1 熊露1 周文娟1，2 陈燕3 王智慧3 万贵平1，2   

  1.  1 南京中医药大学附属中西医结合医院（南京 210028）；2 江苏省中医药研究院（南京 210028）；3 苏州市相 城人民医院（江苏苏州 215131）

  • 出版日期:2022-01-25 发布日期:2022-01-25
  • 通讯作者: 万贵平 E⁃mail：wanguiping@263.net
  • 基金资助:
    江苏省中医药科技发展专项（编号：2020ZX14）；江苏省中医药局第二批科技项目（编号：JD201814）；江苏省卫生计生委医学科研课题（编号：H2018016）

A study on the TCM syndrome types，constitution，and related risk factors of HR ⁃HPV infection in the uterine cervix

ZHOU Fangfang*，GUI Tao，HUANG Meihua，GAN Lin，XIONG Lu，ZHOU Wenjuan，CHEN Yan，WANG Zhihui，WAN Guiping.    

  1. Affiliated Hospital of Integrated Traditional Chinese and Western Medicine， Nanjing University of Chinese Medicine，Nanjing 210028，China 

  • Online:2022-01-25 Published:2022-01-25
  • Contact: WAN Guiping E⁃mail：wanguiping@263.net

摘要：

目的 研究宫颈高危型人乳头状瘤病毒（HR⁃HPV）感染中医证型、体质分布及相关危险因素，为中医药防治提供临床依据。方法 通过流行病学调查分析宫颈HR⁃HPV 感染患者的中医证型、体质 及两者相关性，多因素 logistic 回归分析宫颈 HR⁃HPV 感染相关危险因素。结果 本研究共调查 782 例，其中宫颈 HR⁃HPV 感染 309 例，总体感染率为 39.51%；不同年龄段的感染率分布大致呈“U”形。感染人群多 见脾虚湿热证（50.48%，156/309），体质分布以湿热质（25.89%，80/309）、阳虚质（17.48%，54/309）为主；部 分体质与中医证型联系紧密。多因素回归结果显示，年龄 20 ~ 39 岁、多孕多产和湿热质体质为宫颈 HR⁃ HPV 感染独立危险因素（Ρ < 0.05），平和质体质是保护因素（Ρ < 0.05）。结论 宫颈 HR⁃HPV 感染受到多 因素的影响，临床工作中应做到体、病、证三位一体，及早针对相关危险因素采取干预措施，以达到未病先 防、既病防变、预后防复的效果。

关键词: HR?HPV, 中医证型,  , 中医体质,  , 危险因素,  , 相关性研究

Abstract:

Objective To study the TCM syndrome types，constitution，and related risk factors of HR⁃HPV infection in the uterine cervix，to provide a clinical basis for its prevention and treatment in TCM. Methods The distribution of TCM syndrome types and constitution in patients with cervical HR⁃HPV infection was studied using epidemiological survey methods. Then investigate the relationship between them. Finally，using multivariate Logistic regression analysisto analyse the risk factors related to cervical HR⁃HPV infection. Results This study surveyed 782 people，309 of whom had cervical HR⁃HPV infection，for an overall infection rate of 39.51%. The HR⁃HPV infection rate follows a U⁃shaped distribution based on age. In the infection group，the syndrome of dampness⁃heat due to spleen deficiency was most commonly seen（50.48%，156/309），the TCM constitution types were mainly dampness ⁃ heat constitution（25.89%，80/309）and yang deficiency constitution（17.48%，54/309）. There were significant positive correlations between syndrome of dampness ⁃ heat due to spleen deficiency and dampness ⁃ heat constitution，kidney ⁃yang deficiency syndrome and yang ⁃deficiency constitution，kidney ⁃yin deficiency syndrome and yin⁃deficiency constitution，as well as dampness⁃toxin accumulation syndrome and Phlegm⁃dampness constitu⁃ tion（P < 0.01）. The age range of 20 ~ 39 years，the number of abortions > 2，the number of parturitions > 2，and the dampness ⁃ heat constitution were all independent risk factors for cervical HR ⁃HPV infection （P < 0.05）， while the balanced constitution was a protective factor against cervical HR ⁃HPV infection（P < 0.05）. Conclusion Multiple factors influence HR ⁃HPV infection in the uterine cervix. Clinical work should include identifying the constitution，disease，and TCM syndrome types，as well as taking early interventions against the relevant risk factors， in order to prevent disease before it starts，avoid changes in the disease，and prevent recurrence in the prognosis. 

Key words:

HR?HPV, TCM syndrome types, TCM constitution, risk factors, correlation study

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