关键词:

肠促胰岛素类药物, 体脂肪分布, 肥胖症

Abstract:

Over the past decades, the incidence of obesity has significantly increased. Obesity is associated with many chronic diseases and threatens health of people greatly. The threat of obesity to health is not only related to the degree of obesity, but also to the distribution of body fat. As compared with subcutaneous adipose tissue, vis⁃ ceral and ectopic adipose tissues link more closely to obesity⁃related metabolic diseases. Incretin⁃based drugs can improve body fat distribution in addition to lowering blood glucose and losing weight. Therefore, these types of drugs are more ideal for controlling blood glucose level and weight, and they are potential medications for non⁃alcoholic fatty liver disease. This review summarizes the effects of incretin⁃based drugs glucagon⁃like peptide⁃1 receptor ago⁃ nist and dipeptidyl peptidase 4⁃inhibitors on body fat distribution.

Key words:

incretin?based drugs, body fat distribution, obesity