实用医学杂志 ›› 2021, Vol. 37 ›› Issue (8): 970-973.doi: 10.3969/j.issn.1006⁃5725.2021.08.002

• 新型冠状病毒肺炎专栏 • 上一篇    下一篇

新型冠状病毒肺炎患者新型冠状病毒抗体持续阳性时间的影响因素

李侗曾,梁连春   

  1. 首都医科大学附属北京佑安医院呼吸与感染疾病科(北京 100069)
  • 出版日期:2021-04-25 发布日期:2021-04-25
  • 通讯作者: 梁连春 E⁃mail:llc1215@ccmu.edu.cn

Influencing factors of persistent SARS⁃CoV⁃2 antibody positive test results in patients with COVID⁃19

LI Tongzeng,LIANG Lianchun   

  1.  Department of Respiratory and Infectious Diseases,Beijing You′ an Hospital,Capital Medical University,Beijing 100069,China
  • Online:2021-04-25 Published:2021-04-25
  • Contact: LIANG Lianchun E⁃mail:llc1215@ccmu.edu.cn

摘要:

目的 分析影响新型冠状病毒肺炎(COVID⁃19)患者的新型冠状病毒(SARS⁃CoV⁃2)抗体持续阳性时间的影响因素。方法 回顾性分析我院于 2020 1 21 日至 10 25 日收治并随访时间超过 6 个月的 43 COVID⁃19 患者,比较发病后随访 6 个月时抗体转阴组患者与持续阳性组患者的临床特点。结果 随访超过 6 个月的 43 例患者中,有 10 例(25.6%)患者 SARS⁃CoV⁃2 IgM IgG 均转阴,抗体持续阳性患者的年龄较大、淋巴细胞计数较低、发热比例较高(P < 0.05);多因素回归分析显示淋巴细胞计数较低、发热是患者抗体持续阳性超过 6 个月的独立危险因素。结论 淋巴细胞计数偏低、发热的 COVID⁃19 患者

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Abstract:

Objective To investigate the factors affecting the positive duration of SARS⁃CoV⁃2 antibody in patients with COVID ⁃ 19.Methods A retrospective analysis was made among 43 patients with COVID ⁃ 19 who were followed up for more than 6 months in our hospital from January 21 to October 25,2020. The clinical charac⁃ teristics were compared between those patients with antibody negative test results and those with persistent positive test results after 6 months of follow⁃up. Results After follow⁃up of over 6 months,both SARS⁃CoV⁃2 IgM and IgG tested negative in 10 patients,taking up 25.6%. The patients tested persistently positive were characterized by old age,lower lymphocyte count and higher incidence rate of fever(P < 0.05). Multivariate regression analysis showed that lower lymphocyte count and fever were independently related to the persistent antibody positive test resultsfor more than 6 months. Conclusion The persistent antibody positive test results in COVID ⁃19 patients account for 

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