营养指标与乳腺癌患者临床结局的关系

doi:10.3969/j.issn.1006-5725.2019.16.013

实用医学杂志 ›› 2019, Vol. 35 ›› Issue (16): 2575-2578.doi: 10.3969/j.issn.1006-5725.2019.16.013

营养指标与乳腺癌患者临床结局的关系

彭程¹, 楼慧玲¹, 袁辉辉¹, 陈巧聪¹, 李雯曦¹, 李凌²

华南理工大学第二附属医院,广州市第一人民医院1老年病科,2病案管理科（广州 510180）

收稿日期:2019-03-21 出版日期:2019-08-27 发布日期:2019-08-27
通讯作者: 李凌 E-mail：ling7810@163.com
基金资助:
广东省医学科学研究基金项目（编号：A2019005）; 广州市科技计划项目（编号：201903010091）; 广州市卫生和计划生育委员会一般引导项目（编号：21081A011008）

Relationship between nutritionalmarkers and clinical outcomes in breast cancer patients

PENG Cheng^*, LOU Huiling, YUAN Huihui, CHEN Qiaocong, LI Wenxi, LI Ling

*Department. of Geriatrics, School of Medicine, Guangzhou First People′s Hospital, South China University of Technology, Guangzhou 510180, China

Received:2019-03-21 Online:2019-08-27 Published:2019-08-27
Contact: LI Ling E-mail： ling7810@163.com

摘要/Abstract

摘要： 目的探索营养指标与乳腺癌患者临床结局之间的关系。方法随访队列为2000年1月至2013年12月在广州市第一人民医院就诊,病理诊断为乳腺恶性肿瘤的患者1 319例。使用COX生存分析和Kaplan-Meier生存曲线,分析营养指标与乳腺癌患者术后2年无瘤生存之间的关联。结果经COX生存分析发现,白蛋白（HR = 0.52,95%CI：0.36 ~ 0.76,P = 0.001）、血红蛋白（HR = 0.47,95%CI：0.24 ~ 0.91,P = 0.026）、单核细胞计数（HR = 0.61,95%CI：0.39 ~ 0.94,P = 0.025）和单核细胞比例（HR = 0.59,95%CI：0.39 ~ 0.89,P = 0.012）是乳腺癌患者术后2年无瘤生存的保护因素。结论良好的营养状况是乳腺癌患者术后2年无瘤生存的保护性因素;术前评估患者营养状况并有针对性地给予干预,有助于改善乳腺癌患者的临床结局。

关键词: 营养指标, 乳腺癌, 临床结局

Abstract: Objective To explore the relationship between nutritional markers and clinical outcome in breast cancer patients. Methods A total of 1,319histologically confirmed breast cancer patients were included in this study from Guangzhou First People′s Hospital from Janauary 2010 to October, 2013. COX survival analysis and Kaplan-Meier survival estimate were used to analyze the association between nutritional markers and two-year disease free after the surgery in breast cancer patients. Results COX survival analysis showed albumin（HR = 0.52,95%CI：0.36 ~ 0.76,P = 0.001）, hemoglobin（HR = 0.47,95%CI：0.24 ~ 0.91,P = 0.026）, monocyte number（HR = 0.61,95%CI：0.39 ~ 0.94,P = 0.025） and monocyte ratio（HR = 0.59,95%CI：0.39 ~ 0.89,P = 0.012） were protecting factors associated with two-year disease free after the surgery in breast cancer patients. Conclusion Good nutritional status is a protecting factor of two-year-disease free after the surgery in breast cancer patients and nutrition assessment and proper intervention before the surgery might improve their clinical outcome.

Key words: nutritional markers, breast cancer, clinical outcome

彭程, 楼慧玲, 袁辉辉, 陈巧聪, 李雯曦, 李凌. 营养指标与乳腺癌患者临床结局的关系[J]. 实用医学杂志, 2019, 35(16): 2575-2578.

PENG Cheng, LOU Huiling, YUAN Huihui, CHEN Qiaocong, LI Wenxi, LI Ling. Relationship between nutritionalmarkers and clinical outcomes in breast cancer patients[J]. The Journal of Practical Medicine, 2019, 35(16): 2575-2578.

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营养指标与乳腺癌患者临床结局的关系

Relationship between nutritionalmarkers and clinical outcomes in breast cancer patients

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