光动力疗法在肿瘤治疗中的研究进展

doi:10.3969/j.issn.1006-5725.2019.16.001

实用医学杂志 ›› 2019, Vol. 35 ›› Issue (16): 2517-2521.doi: 10.3969/j.issn.1006-5725.2019.16.001

• 临床新进展 • 下一篇

光动力疗法在肿瘤治疗中的研究进展

陈越¹, 郑军¹, 谭潇^1,2

1三峡大学第一临床医学院,三峡大学肝胆胰外科研究所（湖北宜昌 443003）;
2三峡大学医学院,肿瘤微环境与免疫治疗湖北省重点实验室（湖北宜昌 443002）

收稿日期:2019-03-15 出版日期:2019-08-27 发布日期:2019-08-27
通讯作者: 郑军 E-mail：zhengjundr@163.com;谭潇 E-mail：xiao-tan@hotmail.com
作者简介:郑军，教授、硕士、主任医师、硕士生导师，美国哈佛大学医学院访美学者，宜昌市中心人民医院普外科兼肝胆胰外科主任，三峡大学第一临床医学院外科教研室主任。湖北省医学会普外分会委员，湖北省医学会胰腺病分会委员，宜昌市肝胆胰外科分会主任委员，中国医疗保健国际交流促进会胰腺疾病分会委员，中国研究型医院学会数字医学临床外科专业委员会委员，三峡大学肝胆胰外科研究所所长，宜昌市优秀专家、宜昌市卫生系统第一层次拔尖人才。
以第一作者及通讯作者发表专业学术论文60余篇，其中SCI收录6篇，主持并参与国家自然科学基金课题1项、湖北省自然科学基金项目1项、宜昌市医疗卫生科技计划项目1项，拥有发明专利2项，获宜昌市科技进步一等奖、三等奖。
基金资助:
国家自然科学基金项目（编号：81602743）; 湖北省自然科学基金面上项目（编号：2016CFB152）

Research progresses of photodynamic therapy in treatment of tumor

CHEN Yue^*, ZHENG Jun, TAN Xiao

*The First College of Clinical Medical Science of China Three Gorges University, Institute of Hepatopancreatobilary Surgery, Yichang 443003, China

Received:2019-03-15 Online:2019-08-27 Published:2019-08-27
Contact: ZHENG Jun E-mail： zhengjundr@163.com; TAN Xiao E-mail：xiao-tan@hotmail.com

摘要/Abstract

摘要： 肿瘤是机体在各种致瘤因素作用下,局部组织细胞异常增殖所形成的具有一定侵袭能力的新生物。肿瘤细胞具有异常的形态、代谢和功能,并在不同程度上失去了分化成熟的能力,是当今医学发展的难题。光动力疗法（photodynamic therapy,PDT）是一种基于光敏剂、光照等条件,对病灶细胞具有杀伤作用的治疗手段,其在治疗某些疾病、改善患者预后方面具有诸多优点,尤其对于肿瘤患者而言,PDT的出现可能为他们的治疗带来意想不到的效果。在国内外众多研究报告中,PDT显示出了对不同肿瘤的有效性,这无疑为临床上肿瘤的治疗提供了新的思路。本文选取了PDT在几种常见恶性肿瘤的研究进展进行综述。

关键词: 光动力疗法, 肿瘤, 光敏剂

Abstract: Tumor is caused by various tumorigenic factors. It is a kind of new organism with abnormal proliferation and invasive ability. Tumor cells have abnormal morphology, metabolism and functions. They have no differentiation and maturation ability, and it remains a problem in current medical development. Photodynamic therapy （PDT） is a therapeutic method based on photosensitizers and light, which aims to kill the tumor cells. PDT has many advantages in treatment of several diseases and improvement of prognosis of patients, especially in treatment of tumors. Many research reports showed the efficient effect of PDT in treatment of different tumors, which undoubtedly provides us a novel strategy in clinical trials. This article aims to summarize the use and progress of PDT in several common malignant tumors.

Key words: photodynamic therapy, tumor, photosensitizer

陈越, 郑军, 谭潇. 光动力疗法在肿瘤治疗中的研究进展[J]. 实用医学杂志, 2019, 35(16): 2517-2521.

CHEN Yue, ZHENG Jun, TAN Xiao. Research progresses of photodynamic therapy in treatment of tumor[J]. The Journal of Practical Medicine, 2019, 35(16): 2517-2521.

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光动力疗法在肿瘤治疗中的研究进展

Research progresses of photodynamic therapy in treatment of tumor

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