血清F2-异前列腺素、同型半胱氨酸、胞质型磷脂酶A2与男性勃起功能障碍的关系

doi:10.3969/j.issn.1006-5725.2025.23.015

Abstract

Abstract:

Objective To investigate the relationship between serum F2-isoprostaglandin （F2IP）， homocysteine （Hcy）， cytoplasmic phospholipase A2 （cPLA2） and male erectile dysfunction. Methods A total of 198 patients with erectile dysfunction who were admitted to the Affiliated Hospital of Inner Mongolia Medical University from January 2020 to April 2025 were selected as the case group. Meanwhile， 198 physical examinees with normal reproductive and sexual functions who underwent physical examinations in our hospital during the same period were selected as the control group. The levels of serum F2IP， Hcy， cPLA2， sex hormones， and the score of the international index of erectile function （IIEF） were measured and recorded in the two groups. Subsequently， the diagnostic value of serum F2IP， Hcy， and cPLA2 for male erectile dysfunction was analyzed. Based on the IIEF score， the patients with erectile dysfunction were classified into the severe group （45 cases）， the moderate group （88 cases）， and the mild group （65 cases）. The levels of serum F2IP， Hcy， cPLA2， and sex hormones were compared among the three groups， and the correlation between the levels of serum F2IP， Hcy， cPLA2， sex hormones， and the IIEF score in patients with erectile dysfunction was analyzed. Results The levels of serum F2-isoprostane （F2IP）， homocysteine （Hcy）， cytosolic phospholipase A2 （cPLA2）， follicle-stimulating hormone （FSH）， and luteinizing hormone （LH） in the case group were significantly higher than those in the control group， while the serum testosterone level and International Index of Erectile Function （IIEF） score were significantly lower than those in the control group （P < 0.05）. The area under the curve （AUC） of the combined detection of serum F2IP， Hcy， and cPLA2 in the diagnosis of erectile dysfunction was higher than that of each biomarker alone （P < 0.05）， with the sensitivity and specificity being 88.38% and 84.34%， respectively. In the mild， moderate， and severe groups， the levels of serum F2IP， Hcy， cPLA2， FSH， and LH exhibited an increasing trend， whereas the serum testosterone level showed a decreasing trend （P < 0.05）. The levels of serum F2IP， Hcy， and cPLA2 in patients with erectile dysfunction were negatively correlated with the serum testosterone level and IIEF score （r = -0.573， -0.618， -0.549， -0.516， -0.553， -0.581； P < 0.05） and positively correlated with the levels of serum FSH and LH （r = 0.571， 0.650， 0.650， 0.511， 0.648， 0.547； P < 0.05）. Conclusions The occurrence of erectile dysfunction can lead to an increase in the levels of serum F2IP， Hcy， and cPLA2， as well as an abnormality in the levels of serum sex hormones. Moreover， the combination of serum F2IP， Hcy， and cPLA2 can enhance the diagnostic value of erectile dysfunction. Meanwhile， there is a significant correlation between the levels of serum F2IP， Hcy， and cPLA2， the levels of serum sex hormones， and the severity of the disease.

Key words: erectile dysfunction, F2-isoprostaglandin, homocysteine, cytoplasmic phospholipase A2, sex hormones

CLC Number:

R691.5

Debang LI,Xiaojun ZHU,Pujia. REN. Relationship between serum F2IP， Hcy， cPLA2 and male erectile dysfunction[J]. The Journal of Practical Medicine, 2025, 41(23): 3730-3736.

Figures/Tables 7

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Tab.1

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Fig.2

References 27

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组别	例数	年龄/岁	体质量指数/（kg/m²）	合并高血压/［例（%）］	合并糖尿病/［例（%）］	吸烟史/［例（%）］	饮酒史/［例（%）］
对照组	198	38.95 ± 4.37	22.47 ± 0.56	17（8.59）	8（4.04）	94（47.47）	62（31.31）
病例组	198	39.45 ± 4.16	22.59 ± 0.66	23（11.62）	13（6.57）	112（56.57）	74（37.37）
χ²/t值		1.166	1.951	1.001	1.257	3.278	1.613
P值		0.244	0.052	0.317	0.262	0.070	0.204

组别	例数	F2IP/ （ng/mL）	Hcy/ （μmol/L）	cPLA2/ （pg/mL）	睾酮/ （ng/mL）	卵泡刺激素/（mIU/mL）	黄体生成素/（mIU/mL）	雌二醇/ （pg/mL）	IIEF评分/分
对照组	198	17.86 ± 5.39	14.45 ± 4.86	70.83 ± 8.57	5.45 ± 1.12	5.34 ± 1.27	3.08 ± 0.37	38.53 ± 3.60	24.41 ± 0.49
病例组	198	23.44 ± 6.72	20.37 ± 5.30	79.85 ± 9.70	3.79 ± 0.35	8.69 ± 1.44	7.03 ± 1.42	38.85 ± 4.58	12.34 ± 1.52
t值		9.115	11.584	9.806	19.906	24.551	37.877	0.773	106.347
P值		< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	0.440	< 0.001

指标	截断值	AUC值	95%CI	敏感度/%	特异度/%	约登指数	Z值	P值
F2IP	20.73 ng/mL	0.764	0.719 ~ 0.805	64.14	76.26	0.404	11.170	< 0.001
Hcy	18.39 μmol/L	0.809	0.767 ~ 0.847	69.19	79.29	0.485	14.579	< 0.001
cPLA2	77.37 pg/mL	0.765	0.720 ~ 0.806	62.12	79.80	0.419	11.187	< 0.001
联合		0.931^*#△	0.902 ~ 0.954	88.38	84.34	0.727	34.576	< 0.001

组别	例数	F2IP/ （ng/mL）	Hcy/ （μmol/L）	cPLA2/ （pg/mL）	睾酮/ （ng/mL）	卵泡刺激素/ （mIU/mL）	黄体生成素/ （mIU/mL）	雌二醇/ （pg/mL）
轻度组	65	20.45 ± 2.58	15.36 ± 4.71	74.36 ± 5.97	5.11 ± 0.68	6.19 ± 0.69	5.37 ± 0.77	38.04 ± 2.89
中度组	88	23.39 ± 4.11	23.94 ± 5.63	78.11 ± 6.05	3.37 ± 0.40	9.19 ± 0.84	7.09 ± 0.47	38.52 ± 3.24
重度组	45	27.86 ± 4.29	25.05 ± 4.96	89.23 ± 8.46	2.70 ± 0.35	11.32 ± 0.97	9.31 ± 0.84	39.36 ± 4.30
F值		52.634	65.590	69.559	363.342	541.076	456.891	2.005
P值		< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	0.137

指标	睾酮		卵泡刺激素		黄体生成素		IIEF评分
指标	r值	P值	r值	P值	r值	P值	r值	P值
F2IP	-0.573	< 0.001	0.571	< 0.001	0.650	< 0.001	-0.618	< 0.001
Hcy	-0.549	< 0.001	0.650	< 0.001	0.511	0.017	-0.516	< 0.001
cPLA2	-0.553	< 0.001	0.648	< 0.001	0.547	< 0.001	-0.581	< 0.001

Relationship between serum F2IP， Hcy， cPLA2 and male erectile dysfunction

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