网络出版日期: 2022-02-25
基金资助
省 级 重 点 大 学 生 创 新 创 业 训 练 计 划（编 号 ：202110285044Z）；国 家 自 然 基 金 资 助 项 目（编 号 ：82101972，
81971800）；浙江省自然基金青年项目（编号：LQ19H090010）
Research progress on the effect and underlying mechanism of interleukin ⁃ 38 in central nervous system diseases#br#
Online published: 2022-02-25
蔡陆威 陶陆阳 高原 . 白细胞介素⁃38在中枢神经系统疾病中的作用及潜在性机制研究进展[J]. 实用医学杂志, 2022 , 38(4) : 511 -515 . DOI: 10.3969/j.issn.1006⁃5725.2022.04.023
Interleukin（IL）⁃38，a newly discovered anti⁃inflammatory cytokine in the IL⁃1 family，isexpressed in a variety of tissues and secreted by a variety of cells. By binding to multiple receptors such as IL⁃36R，IL⁃1RAPL1 and IL⁃1R1，IL⁃38 plays an essential role in the physiology and pathogenesis of the central nervoussystem（CNS）. IL⁃38 mitigates pathological damage by inhibiting the expression of Th17 in neuromyelitisoptica.IL⁃38 improves the symptoms of stroke by inhibiting SIRT1/HIF⁃1α signaling pathway. However，the role of IL⁃38in neurological diseases and its potential mechanism need to be further studied. This review systematically and com⁃prehensively summarizes the biological characteristics，pathological effects and potential mechanisms of IL⁃38 un⁃der physiological and pathological conditions，aiming to explore potential molecular targets and new therapeuticstrategies for CNS diseases.
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