1内蒙古科技大学包头医学院（内蒙古包头 014000）；2内蒙古科技大学包头医学院第一附属医院神经外科（内蒙古包头 014000）；3包头医学院神经外科疾病研究所（转化医学）（内蒙古包头 014000）；4内蒙古自治区骨组织再生与损伤修复工程技术中心（内蒙古包头 014000）；5深圳市龙岗区第三人民医院转化医学中心（广东深圳 518172）
网络出版日期: 2022-02-10
基金资助
国家自然科学基金（编号：82160250，81960238）；内蒙古自然科学基金（编号：2020MS08013，2021MS08124）
Application and research progress of stem cells in repair of skull defects
Baotou Medical College of Inner Mongolia University of Science and Technology，Baotou 014000，China；*Department of Neurosurgery，the First Affiliated Hospital of Baotou Medical College of In⁃ner Mongolia University of Science and Technology，Baotou 014000，China；*Institute of Neurosurgical Diseases，Baotou Medical College（Translational Medicine），Baotou 014000，China；*Inner Mongolia Autonomous RegionBone Tissue Regeneration and Damage Repair Engineering Technology Center，Baotou 014000，China
Online published: 2022-02-10
曹志威, 邵国 赵志军, 张春阳,
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干细胞在颅骨缺损修补中的应用及研究进展
Skull defects is a common and important clinical condition in neurosurgery. Using the osteogenicproperties of stem cells to repair bone defects of critical size has become the focus of attention. Application ofvarious stem cells has presently made significant progress in bone tissue engineering. However，how to improve theimplantation rate and survival rate of stem cells is the key to this repair method. Therapies with stem cells for skulldefects have been proven feasible in animal studies，providing a new way for further clinical research. Stem celltransplantation is still the most promising procedure for repairing skull defects.
Key words：
stem cell; transplantation; skull defect; skull repair
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