Objective To investigate the association between the single nucleotide polymorphisms ofAKT1 gene and susceptibility to meningioma. Methods Peripheral venous blood samples were obtained from 200patients who had underwent neurosurgical treatment and been histologically diagnosed as meningioma were includedas the case group and 200 healthy controls in Beijing Tiantan Hospital between October 2017 to January 2018. TheAKT1 gene polymorphisms including rs1130214，rs2494746 and rs2494752 were detected by Multiplex SNaPshotmethods. The association of AKT1 gene polymorphisms with susceptibility to meningioma was analyzed. Results There was no significant difference in genotype and allele frequencies of rs1130214 polymorphism of AKT1 genebetween case group and control group（χ2 = 1.499，P = 0.510）. The genotype and allele distribution frequencies ofAKT1 rs2494746 and rs2494752 polymorphisms were significantly different between case group and control group（rs2494746：χ2 = 9.236，P = 0.010；rs2494752：χ2 = 9.044，P = 0.012）. For the recessive and additive models ofthe rs2494746，individuals with G allele had increased risk of meningiomas（P < 0.05）. Haplotype analysisshowed that the frequencies of three haplotypes（CCA、CGA and CGG）were also significantly different betweencase group and control group（all P < 0.05）. Conclusion The AKT1 gene polymorphisms rs2494746 andrs2494752 are associated with meningioma susceptibility. Genetic variations of the two polymorphism loci signifi⁃cantly increase the risk of meningioma.