随着广谱抗生素的使用，细菌及真菌对抗生素的耐药能力不断上升，临床上可供选择的抗 菌药物愈加有限。生物膜是耐药菌适应环境，产生耐药性的重要手段，而近年来不断有研究表明中药提 取物能够单独或联用传统抗生素在生物膜相关感染中起到很好的抗生物膜作用，表明其很有可能成为抗 耐药菌感染的辅助甚至替代药物。而动物相关研究则是中药走向临床的中药一环。该文将从生物膜耐 药机制以及多种中药提取物单用或联合抗生素使用在体内实验中对不同耐药菌生物膜起到的抑制效果 作一综述，以期为中药应用于临床生物膜相关耐药菌感染提供参考。

 With the use of broad ⁃spectrum antibiotics，the resistance of bacteria and fungi to antibiotics continues to increase，and the clinically available drugs are becoming more limited. Biofilm is an important means for drug ⁃ resistant bacteria to adapt to the environment and produce drug resistance. In recent years，continuous studies have shown that traditional Chinese medicine（TCM）extracts can be used alone or in combination with anti⁃ biotics to play a good anti⁃biofilm effect in biofilm⁃related infections. It suggested that TCM is likely to be an auxil⁃ iary or even an alternative drug for resistant bacterial infections. And in vivo research is a link of TCM to clinical practice. In this review，we will review the mechanism of biofilm resistance and the inhibitory effects of various TCM extracts on biofilms of different drug⁃resistant bacteria in vivo experiments，in order to provide reference for the application of TCM in clinical biofilm⁃related drug resistant bacteria infection。