目的 研究人软骨糖蛋白 39（human cartilage glycoprotein 39，YKL⁃40）、肺表面活性物质相关 蛋白（pulmonary surfatcant⁃associated protein A，SP⁃A）、白细胞介素⁃8（interleukin⁃8，IL⁃8）联合检测对新生儿肺炎的诊断价值及与危重度的关系。方法 本研究以我院2017年1月至2021年1月诊断的新生儿肺炎患者 150例作为病例组，轻症患者82例，重症患者68例，另选取同期出生的健康新生儿150例作为对照组，比较病例组以及对照组、不同严重程度患者的YKL⁃40、SP⁃A及IL⁃8水平，分析YKL⁃40、SP⁃A及IL⁃8联合诊断对新 生儿肺炎的诊断意义。结果 病例组患者的YKL⁃40（t = 29.889，P < 0.001）、IL⁃8（t = 26.725，P < 0.001）显著高 于对照组，SP⁃A（t = 71.258，P < 0.001）显著低于对照组，轻症组患者的 YKL⁃40（t = 4.171，P < 0.001）、IL⁃8 （t = 48.098，P < 0.001）显著低于重症组，SP⁃A（t = 15.482，P < 0.001）显著高于重症组；YKL⁃40、SP⁃A及IL⁃8对 新生儿肺炎的患者的联合诊断特异度显著高于单独检测；通过对新生儿肺炎诊断的ROC曲线分析，联合检测 的 ROC 曲线下面积显著高于单独检测，通过 ROC 曲线分析，YKL⁃40、SP⁃A 及 IL⁃8 的临界值为 32.55 ng/mL、 4.23 ng/mL以及259.36 ng/L；通过相关性分析，新生儿肺炎的严重程度与YKL⁃40以及IL⁃8呈现负相关，与SP⁃A 呈现正相关。结论 YKL⁃40、SP⁃A及IL⁃8联合检测对新生儿肺炎具有一定的诊断价值，与危重度评价有关。

Objective To study the diagnostic value of YKL⁃40，SP⁃A and IL⁃8 combined detection in neonatal pneumonia as well as its significance in determining critical severity. Methods In this study，150 patients with neonatal pneumonia diagnosed in our hospital from January 2017 to January 2021 were selected as the research subjects，including 82 mild patients and 68 severe patients. The control group consisted of another 150 healthy newborns born during the same time period. The levels of YKL⁃40，SP⁃A，and IL⁃8 were compared in the observation group，the control group，and patients of varying severity，and YKL⁃40，SP⁃A and IL⁃8 were analyzed The significance of combined diagnosis in the diagnosis of neonatal pneumonia. Results YKL ⁃40（t = 29.889， P ≤ 0.001）and IL⁃8（t = 26.725，P ≤ 0.001）were significantly higher in the observation group than those of in the control group，while SP⁃A（t = 71.258，P ≤ 0.001）was significantly lower in the observation group than those of in the control group，YKL⁃40（t = 4.171，P ≤ 0.001）and IL⁃8（t = 48.098，P ≤ 0.001）were significantly lower the mild group than those of the control group，and SP⁃A（t = 15.482，P ≤ 0.001）were significantly higher in the observation group than those of the control group；YKL⁃40，SP⁃A，and IL⁃8 effects on neonatal lung cancer，the area under the ROC curve of combined detection was significantly higher than that of single detection，according to the ROC curve analysis. The critical values for YKL ⁃ 40，SP ⁃A and IL ⁃8 were 32.55 ng/mL，4.23 ng/mL and 259.36 ng/mL，respectively，according to the ROC curve analysis. The severity of neonatal pneumonia was found to be negatively correlated with YKL ⁃40 and IL ⁃8，and positively correlated with SP ⁃A using correlation analysis. Conclusion The combination detection of YKL⁃40，SP⁃A，and IL⁃8 is very useful for diagnosing newborn pneu⁃ monia and determining critical severity.