目的 研究载脂蛋白 E（ApoE）和 MTHFR C677T 基因多态性与精神分裂症患病及患者认知功能的关联。方法 收集 2018 年 1 月 1 日至 2020 年 1 月 1 日海南省人民医院和海南省安宁医院诊治的精 神分裂症患者 84 例及同期于海南省人民医院体检健康者 84 例为研究对象，检测 ApoE 和 MTHFR C677T 的 基因型及认知功能，行相关性分析。结果 ApoE 基因型与精神分裂症无关（P > 0.05）；MTHFR C677T 基 因型与精神分裂症有关（P < 0.05），对照组基因以 CT（50%）为主，病例组基因以 TT（36.47）及 CT（45.23%） 为主（P < 0.05）；认知功能的指标评分与精神分裂症有关（P < 0.05）；ApoE 基因型与研究对象的认知功能 无关，MTHFR C677T 基因型与研究对象的认知功能相关（P < 0.05）。结论 ApoE 基因多态性与患精神分 裂症以及认知功能无相关性，MTHFR C677T基因多态性与患精神分裂症以及认知功能有相关性。

Objective To investigate the association of ApoE and MTHFR C677T gene polymorphisms with schizophrenia and cognitive function. Methods A total of 84 schizophrenic patients who were admitted to Hainan Provincial People′s Hospital and Anning Hospital from January 1，2018 to January 1，2020 and 84 healthy subjects who were admitted to Hainan Provincial People′s Hospital during the same period were collected. The geno⁃ types and cognitive function of ApoE and MTHFR C677T were detected and the correlation analysis was performed. Results APOE genotype was not associated with schizophrenia（P > 0.05）. The MTHFR C677T genotype was associated with schizophrenia（P < 0.05）. The genotype was mainly CT（50%）in the control group，whereas was mainly TT（36.47）and CT（45.23%）in the study group（P < 0.05）. The index score of cognitive function was related to schizophrenia（P < 0.05）. APOE genotype was not associated with cognitive function，while MTHFR C677T genotype was associated with cognitive function（P < 0.05）. Conclusions APOE gene polymorphism is not associated with schizophrenia and cognitive function，while MTHFR C677T gene polymorphism is related with schizophrenia and cognitive function.