胶质瘤是一种高度恶性的颅内原发性肿瘤，目前对胶质瘤的治疗主要为手术联合放化疗， 但复杂的发病机制使胶质瘤患者对各种治疗产生抵抗，最终复发死亡，因此需要寻找更多新型手段来治 疗胶质瘤。circRNA（circular RNA）是一类特殊的 RNA 分子，其具有多种多样的生物学功能，其能够通过 与某些致癌基因、miRNA（micro RNA）或功能性蛋白质等生物分子相互作用或通过编码蛋白质对胶质瘤 的发生发展、侵袭转移等生物学行为产生影响，此外，circRNA 对胶质瘤的诊断、治疗与预后评估等方面具 有重要的临床应用价值。深入研究 circRNA 在胶质瘤中的作用机制与其所发挥的生物学作用以及临床应 用价值，为胶质瘤的基因治疗找到一种有效的靶点，也为胶质瘤的新型诊疗方案提供了理论依据。

Glioma is the most prevalent and malignant primary intracranial tumor. At present，the main treatment method for glioma are surgery combined with radiotherapy and chemotherapy. However，similar to any other cancer，chemoresistance contributes majorly to cancer recurrence；TMZ resistance makes the therapeutic actuality worse for glioma patients. CircRNA，as a special kind of noncoding RNA，has a wide range of biological functions. It can affect the occurrence，development，invasion and metastasis of gliomas by interacting with some biomolecules such as oncogenes，miRNA or functional proteins or by coding proteins. The role of circRNA as molecular markers or potential targets will provide promising application perspectives，such as early tumor diagnosis， therapeutic evaluation，prognosis prediction，and even gene therapy for tumors.