目的 探讨新鲜周期 hCG 日孕酮（P4）水平对全胚冷冻周期累积活产率的影响。方法 回顾性分析 2016 年 1 月至 2018 年 12 月本中心行 IVF 第 1 周期治疗的≤ 35 岁使用拮抗剂或者激动剂方案的 全胚冷冻患者资料，按 hCG 日孕酮水平分为四组：组 1（< 0.50 ng/mL，n = 801），组 2（0.50 ~ 1.14 ng/mL， n = 1626），组 3（1.15 ~ 1.49 ng/mL，n = 499）和组 4（≥ 1.50 ng/mL，n = 997），其中以组 2 为对照组。结果 与对照组相比，组 1 优质胚胎率和冷冻胚胎率显著增加（P < 0.01），组 4 优质胚胎率、冷冻胚胎率显著下降 （P < 0.01）。累积活产率组 4 显著低于对照组（69.71% vs. 75.83%，P < 0.001），其他各组差异无统计学意 义。经多因素回归分析显示，与对照组相比，组 4 累积活产率显著降低（AOR = 0.759，95%CI：0.63 ~ 0.91， P < 0.01）；组 1 不会影响全冻周期累积活产率（AOR = 0.901，95%CI：0.74 ~ 1.10，P > 0.05）。结论 hCG 日 P4 ≥ 1.5 ng/mL 显著降低累积活产率，可能与优质胚胎率，冷冻胚胎率下降有关；P4 < 0.5 ng/mL 不会影响胚 胎质量，也不会影响全胚冷冻周期的累积活产率。

Objective To explore the effect of progesterone（P4）level on hCG day on embryo quality， and cumulative live birth rate in freeze⁃all strategy patients. Methods From January 2016 to December 2018， patients under 36 years old with first IVF cycle，antagonist or agonist protocol in freeze⁃all strategy were retrospec⁃ tively analyzed and divided into four groups according to their hCG ⁃day P4 levels：group 1（< 0.50 ng/mL，n = 801），group 2（0.50 ~ 1.14 ng/mL，n = 1 626），group 3（1.15 ~ 1.49 ng/mL，n = 499）and group 4（≥ 1.50 ng/mL， n = 997）. The control group was group 2. Results Compared with the control group，the rate of high⁃quality em⁃ bryos and frozen embryos in group 1 increased significantly（P < 0.01），while that in group 4 decreased significantly （P < 0.01）. The cumulative live rate in group 4 were significantly lower than those in the control group（69.71% vs. 75.83%，P < 0.001）. Multivariate regression analysis showed that group 4 significantly reduced the cumulative live birth rate（AOR = 0.759，95%CI：0.63 ~ 0.91，P < 0.01）；group 1 did not affect the cumulative live birth rate（AOR = 0.901，95%CI：0.74 ~ 1.10，P > 0.05）. Conclusion P4 level ≥ 1.5 ng/mL on hCG day significantly reduced the cumulative live rate，which may relate to the decrease of the high ⁃quality embryo rate and frozen embryo rate；P4 level < 0.5 ng/mL did not affect embryo quality and cumulative live birth rate in freeze⁃all strategy cycles.