Affiliated Hangzhou Chest Hospital,Zheji⁃ ang University School of Medicine,Hangzhou 310003,China
Online published: 2021-06-10
目的 观察支气管镜下肺泡灌洗对支气管扩张并感染者疗效及对 suPAR、sTREM⁃1、CRP 的 影响。方法 选择我院 2017 年 9 月至 2020 年 1 月收治的 107 例支气管扩张合并感染者,遵从患者治疗意 愿将全部患者分为对照组(n = 51)及治疗组(n = 56),对照组予以常规支气管扩张及抗感染治疗;治疗组 在对照组基础上予以支气管镜下肺泡灌洗术。结果 治疗后,观察组临床总有效率为 94.64%显著高于对照组 76.47%(P<0.05);两组 FEV1、FEV1/FVC、SaO2、PaO2 均较治疗前显著上升(P<0.05),且治疗组 FEV1、FEV1/FVC、SaO2、PaO2显著高于对照组(P<0.05);而两组 suPAR、sTREM⁃1、CRP 表达水平均较治疗 前显著减少(P<0.05),且治疗组suPAR、sT REM⁃1、CRP表达水平显著低于对照组(P<0.05)。结论 支气管镜下肺泡灌洗术不仅能够有效增强支气管扩张并感染患者的治疗效果,还能保护肺功能,改善血气指标 水平,减轻其炎症反应,具有临床推广意义。
沈亚青, 余仙娟, 何飞
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支气管镜下肺泡灌洗对支气管扩张并感染者的疗效及对感染指标的影响
Objective To observe the effects of bronchoalveolar lavage under bronchoscope on the efficacy, suPAR,sTREM⁃1 and CRP of bronchiectasis complicated with infection Methods A total of 107 cases of bronchi⁃ ectasis complicated with infection admitted in our hospital from September 2018 to January 2020 were selected. All patients were divided into control group(n = 51)and treatment group(n = 56). The control group received routine bronchodilation and anti⁃infective therapy,and the treatment group was given bronchoalveolar lavage under broncho⁃ scope on the basis of control group. Results After treatment,the total clinical effectiveness rate of the observation group(94.64%)was significantly higher than that of the control group(76.47%)(P ≤ 0.05);the levels of FEV1, FEV1/FVC,SaO2 and PaO2 in both groups were significantly higher than those before treatment,and the levels of FEV1,FEV1/FVC,SaO2 and PaO2 in the treatment group were significantly higher than those in the control group (P ≤ 0.05);the expression levels of suPAR,sTREM⁃1 and CRP in both groups were significantly lower than those before treatment,and the expression levels of suPAR,sTREM⁃1 and CRP in the treatment group were significantly lower than those in the control group(P ≤ 0.05). Conclusions Bronchoalveolar lavage under bronchoscope could not only effectively enhance the therapeutic effect in patients with bronchiectasis and infection,but also protect lung function,improve the level of blood gas,and reduce the inflammatory reaction,which is of clinical significance.
Key words:
bronchoalveolar lavage
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