目的 评估≥ 75 岁新型冠状病毒肺炎（coronavirus infectious disease 2019，COVID⁃19）患者心肌损伤标志物与氨基末端脑钠肽前体（N⁃terminal pro⁃brain natriuretic peptide，NT⁃proBNP）对预后的预测价值。方法 纳入武汉市第一医院收治的141例≥75岁COVID⁃19 患者，分析入院时乳酸脱氢酶（LDH）、肌酸 激酶（CK）、肌酸激酶同工酶（CK⁃MB）、丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）、超敏肌钙蛋白 I（hs⁃TnI）和 NT⁃proBNP 与预后的相关性。结果 141 例患者死亡 18 例（12.8%），男性 11 例（61.1%）。与出院组比较，死亡组患者 LDH >250 IU/L（77.8%）、hs⁃TnI > 26 ng/L（72.2%）、NT⁃proBNP > 1 800 ng/L （72.2%）的比例较高（P < 0.05）。受试者工作特征（ROC）曲线分析，NT⁃proBNP 曲线下面积最大（0.94）， hs⁃TnI 次之（0.88）。当 NT⁃proBNP 为 1 025 ng/L 时，对 COVID⁃19 患者发生院内死亡有较好的预测价值。结论 老年 COVID⁃19 患者心肌损伤及 NT⁃proBNP 水平升高常见，且 NT⁃proBNP 对预后具有较好的预测

Objective To unveil the prognostic effect of myocardial injury markers and NT⁃proBNP on patients aged ≥75 years with coronavirus disease⁃19（COVID⁃19）.Methods A total of 141 consecutive patients aged ≥75 years who were admitted to the hospital between 12th and 19th February 2020. In⁃hospital death，clinical characteristics and myocardial injury markers and NT ⁃ proBNP on admission were obtained from medical records. The association of myocardial markers evaluated by LDH，CK，CK ⁃MB，AST，ALT，hs ⁃TnI，and NT ⁃ proBNP were collected. Results 18（12.8%）patients died，including 11（61.1%）male and 7（38.9%）female. Patients with elevated level of LDH，hs⁃TnI，and NT⁃proBNP had significantly higher risk of death than those in discharged group（P < 0.05）. ROC curve analysis showed that the area under curves of NT⁃proBNP was the highest（0.94）， followed by hs⁃TnI（0.88）. When the cutoff value of NT⁃proBNP was 1 025 ng/L，the positive predictive value was 94.40% ，the negative predictive value was 89.40%. Conclusions Myocardial injury and elevated NT ⁃proBNP levels are common in elderly patients with COVID⁃19，