收稿日期: 2026-05-28
修回日期: 2026-06-24
录用日期: 2026-06-26
网络出版日期: 2026-08-13
基金资助
国家自然科学基金资助项目(32270964)
Immunosuppressive effects and targeted therapeutic strategies of platelet-derived PD-L1 in hematogenous tumor metastasis
Received date: 2026-05-28
Revised date: 2026-06-24
Accepted date: 2026-06-26
Online published: 2026-08-13
血小板是血液中仅次于红细胞的细胞成分，传统上被认为主要是参与止血与血栓形成。血小板表面表达的程序性死亡配体1（PD-L1），可直接抑制T细胞功能；此外，血小板还能通过包裹循环肿瘤细胞（CTCs）形成物理屏障，协同放大免疫抑制信号，构成肿瘤血行转移中的移动免疫屏障。本综述系统总结了血小板PD-L1（pPD-L1）的来源与调控机制，提出pPD-L1介导免疫逃逸的三重抑制模型；继而揭示了pPD-L1作为液体活检标志物，在逆转免疫检查点抑制剂（ICIs）耐药、抑制肿瘤血行转移方面的重要地位，为靶向pPD-L1的精准治疗提供理论依据。
姜佳宬 , 马洁 , 朱伟 . 血小板来源PD-L1在肿瘤血行转移中的免疫抑制效应及其靶向治疗策略[J]. 实用医学杂志, 2026 , 42(15) : 2722 -2729 . DOI: 10.3969/j.issn.1006-5725.2026.15.007
Platelets are the second most abundant cellular component in blood after erythrocytes and have traditionally been recognized primarily for their roles in hemostasis and thrombosis. The expression of programmed death-ligand 1 （PD-L1） on the platelet surface enables direct inhibition of T cell function. Moreover， platelets can form a physical barrier by surrounding circulating tumor cells （CTCs）， thereby amplifying immunosuppressive signals synergistically and establishing a mobile immune barrier during hematogenous tumor metastasis. This review systematically summarizes the origin and regulatory mechanisms of platelet PD-L1 （pPD-L1） and proposes a triple-inhibition model of immune evasion mediated by pPD-L1. Furthermore， it highlights the critical role of pPD-L1 as a liquid biopsy biomarker in reversing resistance to immune checkpoint inhibitors （ICIs） and suppressing hematogenous tumor metastasis， providing a theoretical basis for precision therapies targeting pPD-L1.
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