目的 探讨复方丹参注射液联合硝苯地平治疗妊娠期高血压疾病的临床疗效及其对氧化应激、血管内皮功能相关指标的影响。 方法 采用前瞻性随机对照试验，纳入2023年1月至2025年1月期间廊坊市妇幼保健院产科收治的90例妊娠期高血压疾病患者，将受试者随机分为对照组（n = 45）和观察组（n = 45）。对照组给予硝苯地平缓释片，观察组在此基础上联合复方丹参注射液治疗。比较两组患者治疗效果及治疗前后血清超氧化物歧化酶（superoxide dismutase，SOD）、内皮素-1（endothelin-1，ET-1）、24 h尿蛋白定量水平、血压［收缩压（systolic blood pressure，SBP）、舒张压（diastolic blood pressure，DBP）］及脐动脉血流动力学指标［收缩期峰值流速/舒张末期流速比值（systolic/diastolic ratio，S/D）、阻力指数（resistance index，RI）及搏动指数（pulsatility index，PI）］变化，记录两组患者不良妊娠结局发生情况。 结果 观察组总有效率显著高于对照组（95.56% vs. 80.00%，P < 0.05）。治疗后，两组血清SOD水平均较治疗前升高，ET-1水平均下降，但观察组改善更为显著（P < 0.05）；观察组SBP、DBP及24 h尿蛋白降低幅度均优于对照组（P < 0.05）；观察组PI、RI和S/D的降幅均优于对照组（P < 0.05）。观察组不良妊娠结局发生率显著低于对照组（P < 0.05）。两组均未出现严重药物相关不良反应。 结论 复方丹参注射液联合硝苯地平治疗妊娠期高血压疾病可协同提升血压控制效果，调节氧化应激和血管内皮功能，提示该中西医联合治疗方案具有较好的临床应用前景。

Objective To evaluate the clinical efficacy of compound Danshen injection in combination with nifedipine for hypertensive disorders of pregnancy and to investigate its regulatory effects on oxidative stress and vascular endothelial function. Methods This prospective， controlled study recruited 90 consecutive patients with hypertensive disorders of pregnancy who were admitted to the Department of Obstetrics at Langfang Maternal and Child Health Hospital from January 2023 to January 2025. The participants were randomly allocated to either a control group （n = 45）， which received nifedipine monotherapy， or an observation group （n = 45）， which was administered nifedipine in combination with compound Danshen injection. The treatment efficacy， serum levels of superoxide dismutase （SOD） and endothelin-1 （ET-1）， 24-hour urinary protein quantification， blood pressure ［systolic blood pressure （SBP）， diastolic blood pressure （DBP）］， and umbilical artery hemodynamic parameters ［systolic/diastolic ratio （S/D）， resistance index （RI）， and pulsatility index （PI）］ were compared both before and after treatment. Adverse pregnancy outcomes were also documented. Results The overall response rate was significantly higher in the observation group than in the control group （95.56% vs. 80.00%， P < 0.05）. After treatment， both groups showed increased SOD levels and decreased ET-1 levels， and the degree of improvement was significantly greater in the observation group （P < 0.05）. The observation group had significantly greater reductions in SBP， DBP， and 24-hour urinary protein levels （P < 0.05）. Moreover， compared with the control group， the observation group had larger decreases in PI， RI， and S/D after treatment （P < 0.05）. The incidence of adverse pregnancy outcomes was significantly lower in the observation group （P < 0.05）. No serious drug-related adverse reactions were observed in either group during the treatment period. Conclusions Treatment with Compound Danshen injection in combination with nifedipine significantly facilitated blood pressure stabilization and enhanced oxidative stress and endothelial function indices in patients with hypertensive disorders of pregnancy. Therefore， this combination therapy may represent a more effective and clinically valuable intervention compared to conventional treatment alone.