论著·机制与实践

不同胆总管直径对胆总管结石患者腹腔镜胆总管一期缝合术治疗效果及胆道相关并发症的影响

  • 杨波 ,
  • 刘兴贵 ,
  • 肖晶晶 ,
  • 莫立显 ,
  • 孙建洪 ,
  • 覃应茂 ,
  • 李俊阳 ,
  • 刘得元
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  • 1.贵州医科大学第三附属医院肝胆外科(贵州都匀 558000 )
    2.贵州省人民医院肝胆外科 (贵州 贵阳 550002 )

收稿日期: 2026-01-27

  网络出版日期: 2026-06-15

基金资助

国家自然科学基金资助项目(82360483)

Influence of different common bile duct diameters on the therapeutic effect of laparoscopic common bile duct primary suture and biliary tract-related complications in patients with common bile duct stones

  • Bo YANG ,
  • Xinggui LIU ,
  • Jingjing XIAO ,
  • Lixian MO ,
  • Jianhong SUN ,
  • Yingmao QIN ,
  • Junyang LI ,
  • Deyuan LIU
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  • 1.Department of Hepatobiliary Surgery,the Third Affiliated Hospital of Guizhou Medical University,Duyun 558000,Guizhou,China
    2.Department of Hepatobiliary Surgery,Guizhou Provincial People's Hospital,Guiyang 550002,Guizhou,China

Received date: 2026-01-27

  Online published: 2026-06-15

摘要

目的 探讨不同胆总管直径(common bile duct diameter,CBDD)对行腹腔镜胆总管探查术(laparoscopic common bile duct exploration,LCBDE)联合一期缝合术治疗胆总管结石患者的临床疗效、安全性及术后胆道相关并发症的影响,为临床手术适应证的选择提供参考依据。 方法 回顾性分析2022年3月至2025年9月贵州医科大学第三附属医院肝胆外科收治的103例行LCBDE联合一期缝合术治疗胆总管结石患者的临床及随访资料。根据术前核磁测定以及术中测定的胆总管外径将患者分为细径组(A组,0.6 cm ≤ CBDD < 1.0 cm,n = 42)与扩张组(B组,CBDD ≥ 1.0 cm,n = 61)。对比分析两组患者的基线特征、手术相关精细指标、术后肝功能动态恢复情况及并发症发生率。 结果 两组术前基线资料差异无统计学意义(P > 0.05)。A组手术时间及术后住院时间均长于B组(P < 0.05),胆总管切口长度短于B组(P < 0.05);两组术后第1天(POD1)、术后第3天(POD3)谷丙转氨酶(ALT)、总胆红素(TBIL)水平均较术前显著下降(P < 0.05),且组间同期比较差异无统计学意义(P > 0.05);两组术后并发症总发生率差异无统计学意义(P > 0.05),其中A组发生胆漏3例(7.14%),B组发生2例(3.28%),均为ISGLS A级胆漏,经保守治疗痊愈,差异无统计学意义(P > 0.05)。 结论 CBDD < 1.0 cm并非一期缝合的绝对禁忌证,虽然细径胆管增加了手术难度,延长了手术时间及住院时间,但其并不阻碍术后肝功能的快速恢复,且未显著增加严重胆漏等并发症风险,临床疗效确切。

本文引用格式

杨波 , 刘兴贵 , 肖晶晶 , 莫立显 , 孙建洪 , 覃应茂 , 李俊阳 , 刘得元 . 不同胆总管直径对胆总管结石患者腹腔镜胆总管一期缝合术治疗效果及胆道相关并发症的影响[J]. 实用医学杂志, 2026 , 42(11) : 2049 -2055 . DOI: 10.3969/j.issn.1006-5725.2026.11.020

Abstract

Objective To explore the influence of different common bile duct diameters (CBDD) on the clinical efficacy, safety, and postoperative biliary tract-related complications in patients with common bile duct stones who receive laparoscopic common bile duct exploration (LCBDE) combined with primary suture, aiming to provide a reference basis for the selection of clinical surgical indications. Methods The clinical and follow-up data of 103 patients with common bile duct stones who were treated with LCBDE combined with primary suture were retrospectively analyzed in the Department of Hepatobiliary Surgery of the Third Affiliated Hospital of Guizhou Medical University from March 2022 to September 2025. Based on the outer diameter of the common bile duct measured by preoperative magnetic resonance imaging (MRI) and intraoperative measurement, the patients were divided into the small-diameter group (Group A, 0.6 cm ≤ CBDD < 1.0 cm, n = 42) and the dilation group (Group B, CBDD ≥ 1.0 cm, n = 61). The baseline characteristics, surgery-related detailed indicators, postoperative dynamic recovery of liver function, and incidence rates of complications were compared and analyzed between the two groups of patients. Results There were no statistically significant differences in preoperative baseline data between the two groups (P > 0.05). In comparison with group B, group A had a longer surgical time and a longer postoperative hospital stay (P < 0.05), as well as a shorter common bile duct incision length (P < 0.05). The levels of alanine aminotransferase (ALT) and total bilirubin (TBIL) on the 1st day after surgery (POD1) and the 3rd day after surgery (POD3) in both groups decreased significantly compared to the preoperative levels (P < 0.05), and there were no statistically significant differences between the groups at the same time-points (P > 0.05). The overall incidence rate of postoperative complications showed no statistically significant difference between the groups (P > 0.05). Specifically, group A had 3 cases (7.14%) of bile leakage, whereas group B had 2 cases (3.28%). These 5 cases were classified as ISGLS grade A bile leakage and resolved with conservative treatment, with no statistically significant difference between the groups (P > 0.05). Conclusions CBDD < 1.0 cm is not an absolute contraindication for primary suture. Although a small-diameter bile duct increases the difficulty of surgery, prolongs the surgical time, and extends the hospital stay, it does not impede the rapid recovery of postoperative liver function and does not significantly increase the risk of complications such as severe bile leakage, with definite clinical efficacy.

参考文献

[1] YE H W, LIU F, GU D J, et al. Clinical safety study of laparoscopic common bile duct exploration and primary suture in elderly patients: A new strategy for the treatment of stones[J]. BMC Surg, 2025, 25(1): 401-404. doi: 10.1186/s12893-025-03146-7 .
[2] WU D, JIN W, ZHANG Y, et al. Primary Suture of the Common Bile Duct: Continuous or Interrupted?[J]. J Laparoendosc Adv Surg Tech Am, 2022, 32(4): 390-394. doi: 10.1089/lap. 2021.0215 .
[3] 于恒海, 魏晓平. 腹腔镜胆总管探查术中T管,双J管引流与单纯一期缝合的应用比较[J]. 中国普通外科杂志, 2022, 31(8): 1017-1023. doi: 10.1007/s13304-023-01451-5 .
[4] ZHANG D, MA Y, SUN W, et al. Primary suture for patients of bile duct stones after laparoscopic biliary tract exploration: A retrospective cohort study[J]. Updates Surg, 2023, 75(4): 897-903. doi: 10.1007/s13304-023-01451-5 .
[5] YE H W, LIU F, GU D J, et al. Correction: Clinical safety study of laparoscopic common bile duct exploration and primary suture in elderly patients: A new strategy for the treatment of stones[J]. BMC Surg, 2025, 25(1): 529-531. doi: 10.1186/s12893-025-03248-2 .
[6] ZHUANG L, LI Y, ZHANG L, et al. A comparison of the therapeutic outcomes between primary duct closure and T-tube drainage after laparoscopic common bile duct exploration: A single-centre retrospective study[J]. Wideochir Inne Tech Maloinwazyjne, 2023, 18(1): 108-116. doi: 10.5114/wiitm.2022.120672 .
[7] LAI W, XU N. Feasibility and safety of choledochotomy primary closure in laparoscopic common bile duct exploration without biliary drainage: A retrospective study[J]. Sci Rep, 2023, 13(1): 22473-22475. doi: 10.1038/s41598-023-49173-3 .
[8] LU J, ZHANG X, ZENG C, et al. Clinical Analysis of Laparoscopic Common Bile Duct Primary Suture and T-Tube Drainage in the Treatment of Common Bile Duct Stones[J]. J Laparoendosc Adv Surg Tech A, 2023, 33(7): 622-625. doi: 10.1089/lap. 2022.0485 .
[9] 冯其柱, 陈先志, 孙杰, 等. 老年胆总管结石合并急性胆管炎患者ERCP术后胆总管结石复发的危险因素分析[J]. 实用医学杂志, 2023, 39(15): 1945-1949. doi: 10.3969/j.issn.1006-5725.2023.15.015 .
[10] WANG Y, TAN Y, LI J, et al. Double-Needle Bidirectional Barbed Wire Continuous Layered Suture Technique for Laparoscopic Stage I Common Bile Duct Surgery[J]. J Laparoendosc Adv Surg Tech A, 2024, 34(9): 851-854. doi: 10.1089/lap. 2024.0149 .
[11] 张吉祥, 何希平, 张娟, 等. 腹腔镜胆囊切除术+LCBDE胆管一期缝合术与ERCP+腹腔镜胆囊切除术两种手术方式的疗效和安全性对比[J]. 实用医学杂志, 2021, 37(12): 6. doi: 10.3969/j.issn.1006 .
[12] MEHENDALE V G, KAMDAR M S, SHENOY S N. Pragmatic algorithm for management of common bile duct calculi in resource-limited settings in India[J]. J Minim Access Surg, 2024, 20(4): 420-425. doi: 10.4103/jmas.jmas_293_23 .
[13] ZHOU H, HE Y, CHANG L. Comparative study of Indocyanine Green fluorescence imaging versus conventional fiber-optic imaging in laparoscopic choledochotomy for stone extraction and immediate biliary incision suturing[J]. Updates Surg, 2024, 76(6): 2247-2254. doi: 10.1007/s13304-024-01993-2 .
[14] NAGATA T, ARIMURA Y, KOJO M, et al. Laparoscopic Common Bile Duct Exploration for Choledocholithiasis in a Patient with Situs Inversus Totalis and Prior Total Gastrectomy with Roux-en-Y Reconstruction: A Case Report[J]. Surg Case Rep, 2025, 11(1): 25-28. doi: 10.70352/scrj.cr.25-0608 .
[15] HUA X, WANG G, LI B, et al. Comparison of the efficacy of laparoscopic primary closure of the common bile duct and T-tube drainage in the treatment of choledocholithiasis in elderly patients[J]. BMC Geriatr, 2025, 25(1): 549-552. doi: 10.1186/s12877-025-06210-2 .
[16] SUN Y, ZHOU S, TANG S, et al. Laparoscopic primary suture of the common bile duct in patients with common bile duct stones: A comparative analysis of two suturing methods in terms of safety, efficacy, and convenience with 16-month follow-up[J]. BMC Surg, 2025, 25(1): 155-157. doi: 10.1186/s12893-025-02904-x .
[17] XU S, XU M. Clinical Effect of Primary Suture After Laparoscopic Common Bile Duct Exploration for Elderly Patients With Gallbladder Stones and Common Bile Duct Stones[J]. Am Surg, 2026, 92(1): 201-208. doi: 10.1177/00031348251358435 .
[18] LIU L, ZHOU T, CAO Y, et al. Clinical Evaluation of Primary Suturing of Normal-Diameter Common Bile Ducts After Microincision of Cystic Duct Confluence for Stone Removal[J]. Surg Laparosc Endosc Percutan Tech, 2024, 34(4): 419-423. doi: 10.1097/SLE.0000000000001299 .
[19] BRONSWIJK M, G?KCE E, HINDRYCKX P, et al. Single-session endoscopic ultrasound-directed transgastric endoscopic retrograde cholangiopancreatography with a dedicated over-the-scope fixation device: Feasibility study (with video)[J]. Dig Endosc, 2025, 37(2): 176-182. doi: 10.1111/den.14879 .
[20] JI H, HOU Y, CHENG X, et al. Association of Laparoscopic Methods and Clinical Outcomes of Cholecystolithiasis Plus Choledocholithiasis: A Cohort Study[J]. Turk J Gastroenterol, 2023, 34(1): 35-42. doi: 10.5152/tjg.2022.22110 .
[21] NAGATA T, ARIMURA Y, KOJO M, et al. Laparoscopic Common Bile Duct Exploration for Choledocholithiasis in a Patient with Situs Inversus Totalis and Prior Total Gastrectomy with Roux-en-Y Reconstruction: A Case Report[J]. Surg Case Rep, 2025, 11(1): 25-29. doi: 10.70352/scrj.cr.25-0608 .
[22] PADILLA ZEGARRA E D, MEMBA IKUGA R, CORONADO LLANOS D, et al. Primary choledochorraphy after laparoscopic common bile duct exploration: Comparative study of 3 different methods, safety, and efficacy[J]. J Gastrointest Surg, 2025, 29(9): 102122-102125. doi: 10.1016/j.gassur.2025.102122 .
[23] RENDELL V R, PAULI E M. Laparoscopic Common Bile Duct Exploration[J]. JAMA Surg, 2023, 158(7): 766-767. doi: 10.1001/jamasurg.2022.8141 .
[24] HUANG J, HU W, LIU J, et al. Laparoscopic Transcystic Common Bile Duct Exploration: 8-Year Experience at a Single Institution[J]. J Gastrointest Surg, 2023, 27(3): 555-564. doi: 10.1007/s11605-023-05594-z .
[25] DAS S, JHA A K, KUMAR M. Laparoscopic common bile duct exploration in cases of common bile duct stones: Can LCBDE replace ERCP as first line treatment[J]. Am J Surg, 2023, 226(2): 290-292. doi: 10.1016/j.amjsurg.2023.03.006 .
[26] RAMSER B, COLEOGLOU CENTENO A, FERRE A, et al. Laparoscopic common bile duct exploration is an effective, safe, and less-costly method of treating choledocholithiasis[J]. Surg Endosc, 2024, 38(10): 6076-6082. doi: 10.1007/s00464-024-11139-5 .
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