心脑血管疾病专栏

重复经颅磁刺激联合中频电疗法治疗脑卒中后神经源性膀胱的疗效观察

  • 李孟玉 ,
  • 田睿思 ,
  • 郜乐 ,
  • 刘峻江 ,
  • 王婧 ,
  • 方德玺 ,
  • 李艳霞
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  • 1.新疆医科大学护理学院(新疆乌鲁木齐 830017);新疆医科大学第二附属医院2. 康复医学科
    3.泌尿外科
    4.超声科 (新疆 乌鲁木齐 830063 )

收稿日期: 2026-02-26

  网络出版日期: 2026-06-15

基金资助

国家自然科学基金资助项目(82460454);新疆维吾尔自治区自然科学基金资助项目(2022D01C276);新疆维吾尔自治区自然科学基金资助项目(2022D01C120)

Efficacy of repetitive transcranial magnetic stimulation combined with medium frequency electrotherapy for post-stroke neurogenic bladder

  • Mengyu LI ,
  • Ruisi TIAN ,
  • Le GAO ,
  • Junjiang LIU ,
  • Jing WANG ,
  • Dexi FANG ,
  • Yanxia LI
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  • 1.School of Nursing,Xinjiang Medical University,Urumqi 830017,Xinjiang,China
    2.Departments of Rehabilitation Medicine,the Second Affiliated Hospital of Xinjiang Medical University,Urumqi 830063,Xinjiang,China
    3.Departments of Urology,the Second Affiliated Hospital of Xinjiang Medical University,Urumqi 830063,Xinjiang,China
    4.Departments of Ultrasound,the Second Affiliated Hospital of Xinjiang Medical University,Urumqi 830063,Xinjiang,China

Received date: 2026-02-26

  Online published: 2026-06-15

摘要

目的 观察重复经颅磁刺激(rTMS)联合中频电疗法(MFE)在脑卒中后神经源性膀胱(PSNB)患者中的临床疗效。 方法 2024年10月到2025年12月,选取PSNB患者随机分为对照组(n = 30,常规治疗及康复+ MFE)和观察组(n = 30,常规治疗及康复+ rTMS+ MFE)。两组均治疗2周,并随访1个月。比较治疗前后两组临床指标:尿流动力学参数[最大尿流率(Qmax)、最大尿流率时最大逼尿肌压力(PdetQmax)、初始尿意容量(FDV)、最大膀胱容量(MCC)、最大充盈时膀胱内压(Pves at MCC)]、残余尿量(RUV)、排尿日记(日均排尿次数、日均漏尿次数、单次排尿量)、神经源性膀胱症状评分(NBSS)、生活质量指数评分(Qualiveen量表)并评价两组患者疗效及安全性。 结果 治疗后,两组患者FDV、MCC、Qmax、PdetQmax及日均单次排尿量均增加,且观察组高于对照组(P < 0.05);Pves、RUV、日均排尿及漏尿次数、NBSS、Qualiveen量表评分均降低,且观察组低于对照组(P < 0.05);观察组患者总有效率93.33%高于对照组73.33%(P < 0.05)。两组患者均未出现严重不良反应。 结论 rTMS结合MFE应用于PSNB患者康复疗效明显,对改善临床症状、膀胱功能、生活质量有积极意义,且安全性高,患者获益显著。

本文引用格式

李孟玉 , 田睿思 , 郜乐 , 刘峻江 , 王婧 , 方德玺 , 李艳霞 . 重复经颅磁刺激联合中频电疗法治疗脑卒中后神经源性膀胱的疗效观察[J]. 实用医学杂志, 2026 , 42(11) : 1899 -1905 . DOI: 10.3969/j.issn.1006-5725.2026.11.002

Abstract

Objective To explore the clinical efficacy and practical application value of repetitive transcranial magnetic stimulation (rTMS) combined with medium-frequency electrotherapy in the rehabilitation management of patients with post-stroke neurogenic bladder. Methods From October 2024 to December 2025, patients with PSNB were randomly assigned to a control group (n = 30, receiving conventional treatment, rehabilitation, and medium-frequency electrotherapy) and an observation group (n = 30, receiving conventional treatment, rehabilitation, rTMS, and medium-frequency electrotherapy). Both groups underwent treatment for 2 weeks and were then followed up for 1 month. The clinical indicators of the two groups were compared before and after treatment, including urodynamic parameters [initial urge volume (FDV), maximum bladder capacity (MCC), filling phase bladder pressure (Pves at MCC), maximum urine flow rate (Qmax), maximum detrusor pressure at maximum urine flow rate (PdetQmax)], residual urine volume (RUV), voiding diary (average daily voiding frequency, average daily leakage frequency, single void volume), neurogenic bladder symptom score (NBSS), and quality of life index score (Qualiveen scale). The efficacy and safety of the two groups of patients were also evaluated. Results After treatment, the FDV, MCC, Qmax, PdetQmax, and the average daily single urine volume of both groups increased. Statistically, the levels in the observation group were higher than those in the control group (all P < 0.05). Meanwhile, Pves, RUV, the average daily urine volume, the number of leakage episodes, the NBSS score, and the Qualiveen scale score all decreased. Significantly, the values in the observation group were lower than those in the control group (all P < 0.05). The total effective rate in the observation group (93.33%) was significantly higher than that in the control group (73.33%) (P < 0.05). During the entire intervention period, neither group experienced serious adverse events. Conclusions The combination of rTMS and medium-frequency electrotherapy has demonstrated remarkable efficacy in the rehabilitation treatment of patients with PSNB. It plays a positive role in enhancing clinical symptoms, bladder function, and the quality of life. Moreover, it is highly safe, bringing substantial benefits to patients.

参考文献

[1] WANG J, XIAO C, CHENG Z, et al. Analysis and prediction of disease burden of stroke and its subtypes in China from 1990 to 2040[J]. Chin Med J, 2025, 138(19): 2452-2463. doi:10.1097/cm9.0000000000003725 .
[2] SEVILLA TORRES E, SOTO-JUNCO E J, BAIZAN ORIAS S D, et al. Neurogenic voiding dysfunction in spinal cord injury and stroke: Urodynamic evaluation, functional classification, and therapeutic strategies[J]. Cureus, 2025, 17(8): e89348. doi:10.7759/cureus.89348 .
[3] 魏衍旭, 张思鈺, 任慧, 等. 盆底重复磁刺激联合排尿功能训练治疗脑卒中后非认知功能障碍性神经源性膀胱的临床效果[J]. 中国老年学杂志, 2025, 45(11): 2659-2662. doi:10.3969/ j.issn.1005-9202.2025.11.024 .
[4] WANG Y, DONG T, LI X, et al. Research progress on the application of transcranial magnetic stimulation in spinal cord injury rehabilitation: A narrative review[J]. Front Neurol, 2023, 14: 1219590. doi:10.3389/fneur.2023.1219590 .
[5] CHEN J, TAN B, CHEN Y, et al. A randomized controlled trial of low-frequency repeated transcranial magnetic stimulation in patients with poststroke neurogenic bladder[J]. Sci Rep, 2024, 14: 18404. doi:10.1038/s41598-024-69345-z .
[6] DAIA C, BUMBEA A, BADIU C, et al. Interferential electrical stimulation for improved bladder management following spinal cord injury[J]. Biom Rep, 2019, 11(3): 115-122. doi:10.3892/br.2019.1227 .
[7] JIA J. Exploration on neurobiological mechanisms of the central–peripheral–central closed-loop rehabilitation[J]. Front Cell Neurosci, 2022, 16: 982881. doi:10.3389/fncel.2022.982881 .
[8] 中华人民共和国国家卫生健康委员会. 脑血管病防治指南(2024年版)[J]. 磁共振成像, 2025, 16(1): 1-8. doi:10.12015/ issn.1674-8034.2025.01.001 .
[9] 王毅, 赵耀瑞. 卒中后神经源性膀胱诊治专家共识[J]. 中国卒中杂志, 2016, 11(12): 1057-1066.
[10] 孙婉婷, 艾丽皮乃·亚森, 龚翔, 等. 基于运动序列学习探讨高频重复经颅磁刺激对脑卒中患者上肢功能的效果[J]. 中国康复理论与实践, 2025, 31(7): 812-821. doi:10.3969/j.issn. 1006-9771.2025.07.008 .
[11] NARDONE R, VERSACE V, SEBASTIANELLI L, et al. Transcranial magnetic stimulation and bladder function: A systematic review[J]. Clin Neurophysiol, 2019, 130(11): 2032-2037. doi:10.1016/j.clinph.2019.08.020 .
[12] CARRO D F, SILVEIRA L T Y DA, BARACAT E C, et al. Validity and reliability study of a free mobile app for assessing voiding habits[J]. Int J Med Inform, 2026, 207: 106183. doi:10.1016/j.ijmedinf.2025.106183 .
[13] WELK B, LENHERR S, ELLIOTT S, et al. The Neurogenic Bladder Symptom Score (NBSS): A secondary assessment of its validity, reliability among people with a spinal cord injury[J]. Spinal Cord, 2018, 56(3): 259-264. doi:10.1038/s41393-017-0028-0 .
[14] BAUER S, GRASSNER L, MAIER D, et al. Early sacral neuromodulation: A promising opportunity or an overload for patients with a recent spinal cord injury? a cross-sectional study[J]. J Clin Med, 2025, 14(3): 1031. doi:10.3390/jcm14031031 .
[15] 董艳, 刘震钢, 刘媛, 等. 火针联合膀胱功能训练治疗脊髓损伤所致神经源性膀胱: 随机对照试验[J]. 中国针灸, 2024, 44(12): 1395-1400. doi: 10.13703/j.0255-2930.20240316-k0001 .
[16] 许艳, 王凤丽, 耿德勤. 高频重复经颅磁刺激联合丁苯酞对缺血性脑卒中患者肢体功能的作用[J]. 实用医学杂志, 2026, 42(4): 618-625. doi:10.3969/j.issn.1006-5725.2026.04.011 .
[17] AGAPIOU E, PYRGELIS E S, MAVRIDIS I N, et al. Lower urinary tract dysfunction following stroke: From molecular mechanisms to clinical anatomy[J]. J Biol Meth, 2024, 11(4): e99010024. doi:10.14440/jbm.2024.0022 .
[18] 刘敏琦, 高明威, 褚晓蕾, 等. 不同频率电刺激促进周围神经损伤的恢复[J]. 中国组织工程研究, 2025, 29(14): 3061-3069. doi:10.12307/2025.620 .
[19] 袁泽峰, 田高源, 黄志伟, 等. 生物反馈联合磁电刺激对盆底痉挛综合征患者排粪梗阻的改善作用[J]. 实用医学杂志, 2025, 41(15): 2372-2380. doi:10.3969/j.issn.1006-5725.2025. 15.012 .
[20] BROWN J C, PHILIP N S. Pharmaco-transcranial magnetic stimulation: Letting mechanism guide the way[J]. Am J Psychiatry, 2025, 182(3): 240-242. doi:10.1176/appi.ajp.20241151 .
[21] SHARBAFSHAAER M, CIRILLO G, ESPOSITO F, et al. Harnessing brain plasticity: The therapeutic power of repetitive transcranial magnetic stimulation (rTMS) and Theta burst stimulation (TBS) in neurotransmitter modulation, receptor dynamics, and neuroimaging for neurological innovations[J]. Biomedicines, 2024, 12(11): 2506. doi:10.3390/biomedicines12112506 .
[22] ATAK ?AKIR P, MUTLUAY F, HANO?LU L, et al. Effect of transcutaneous posterior tibial nerve stimulation and repetitive transcranial magnetic stimulation on neurogenic overactive bladder symptoms in female patients with multiple sclerosis: The study protocol of a randomized controlled study[J]. Front Neurol, 2022, 13: 1011502. doi:10.3389/fneur.2022.1011502 .
[23] XIE H, LI X, WANG Y, et al. Differential functional network remodeling induced by low- and high-frequency rTMS: Evidence from concurrent fNIRS monitoring[J]. IEEE Trans Neural Syst Rehabil Eng, 2025, 33: 3827-3836. doi:10.1109/TNSRE.2025. 3611796 .
[24] SINHA S, GAJEWSKI J B, TARCAN T, et al. Is it possible to regenerate the underactive detrusor? part 2. electrical stimulation therapies, treatment of bladder outlet obstruction, constipation, and pelvic floor disorders-ICI-RS 2024[J]. Neurourol Urodyn, 2025, 44(3): 585-591. doi:10.1002/nau.25594 .
[25] 中国残疾人康复协会康复评定专业委员会, 甘肃省残疾人康复学会脊柱脊髓损伤康复专业委员会, 甘肃省医学会物理医学与康复分会, 等. 神经源性膀胱综合管理临床实践指南(下)[J]. 中华物理医学与康复杂志, 2025, 47(1): 1-6. doi:10.3760/cma.j.cn421666-20240703-00545-1 .
[26] HAAKANA P, N?TKYNM?KI A, KIRVESKARI E, et al. Effects of auricular vagus nerve stimulation and electrical earlobe stimulation on motor-evoked potential changes induced by paired associative stimulation[J]. Eur J Neuroscience, 2024, 60(8): 5949-5965. doi:10.1111/ejn.16539 .
[27] 娄晓乐, 宋佳苧, 韩雪, 等. 经颅联合外周双向反馈磁刺激对脊髓损伤后神经源性膀胱患者膀胱及排尿功能的效果[J]. 实用医学杂志, 2025, 41(6): 859-865. doi:10.3969/j.issn.1006-5725.2025.06.013 .
[28] ALI M U. Repetitive transcranial magnetic stimulation for the treatment of neurogenic overactive bladder in stroke survivors[D]. Hong Kong: The Hong Kong Polytechnic University, 2025. doi:10.1016/j.mehy.2024.111300
[29] 金娟, 周钦钦, 刘炜, 等. 盆底肌电刺激治疗脊髓损伤后神经源性膀胱的随机对照试验的Meta分析[J]. 中华物理医学与康复杂志, 2021, 43(1): 64-68. doi:10.3760/cma.j.issn.0254-1424.2021.01.018 .
[30] LIU Y, XU G, GENG J. Efficacy of transcutaneous electrical nerve stimulation in the management of neurogenic overactive bladder: A randomized controlled trial[J]. Am J Phys Med Rehabil, 2022, 101(1): 2-10. doi:10.1097/PHM. 0000000000001836 .
[31] GU J, ZANG J. Clinical efficacy of bladder function training combined with pelvic floor biofeedback electrical stimulation on neurogenic bladder and its impact on urodynamics[J]. Pak J Med Sci, 2024, 41(1): 251-256. doi:10.12669/pjms.41.1.9655 .
[32] ATAK ?AKIR P, GüZELBUR? V, BIRDAY E, et al. Effect of neuromodulation on neurogenic bladder in women with multiple sclerosis: A pilot randomized controlled trial[J]. Neurodegener Dis Manag, 2025, 15(2-3): 57-64. doi:10.1080/17582024.2025. 2488712 .
[33] 黄强, 李春宁, 解鸿宇, 等. “灸刺任脉” 联合膀胱功能训练治疗卒中后神经源性膀胱: 随机对照试验[J]. 中国针灸, 2025, 45(10): 1427-1433. doi:10.13703/j.0255-2930.20250302-0001 .
[34] 朱光跃, 陈思韵, 霍聪聪, 等. 外周联合中枢双靶磁刺激促进脑卒中运动功能障碍康复专家共识[J]. 中国康复医学杂志, 2023, 38(7): 880-884. doi:10.3969/j.issn.1001-1242.2023.07.003 .
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