目的 探究消肿透脓汤联合抗生素治疗湿热型阑尾周围脓肿患者的临床疗效。 方法 纳入64例湿热型阑尾周围脓肿患者，按随机数字法分为两组，每组32例。对照组在常规治疗的基础上给予抗生素治疗，观察组在对照组的基础上加服消肿透脓汤治疗。比较两组治疗前后脓肿消退时间、抗生素使用时间、体温恢复正常时间、中医证候评分、疼痛视觉模拟评分、实验室指标、疗效以及不良反应发生率。 结果 观察组脓肿消失时间、抗生素使用时间、体温恢复正常时间较对照组显著缩短（P < 0.001），观察组中医证候评分、疼痛视觉模拟评分、实验室指标较对照组显著降低（P < 0.05），观察组疗效等级显著高于对照组（P < 0.001），两组不良反应发生率比较差异无统计学意义（P > 0.05）。 结论 消肿透脓汤联合抗生素治疗湿热型阑尾周围脓肿患者疗效显著，能有效缩短患者治疗周期，改善临床症状。

Objective To evaluate the clinical efficacy of Xiaozhong Tounong Decoction in combination with antibiotics in patients with periappendiceal abscess of damp-heat syndrome. Methods A total of 64 eligible patients were recruited and randomly allocated into two groups， with 32 patients in each group. The control group underwent conventional treatment using antibiotics， whereas the experimental group received additional treatment with Xiaozhong Tounong Decoction. The primary and secondary outcome measures encompassed the time for abscess resolution， the duration of antibiotic administration， the time to defervescence， traditional Chinese medicine syndrome scores， visual analogue scale pain scores， inflammatory laboratory indicators， overall clinical efficacy， and the incidence of adverse events. Results Compared with the control group， the experimental group exhibited significantly shorter durations in abscess resolution， antibiotic use， and defervescence， along with notably lower scores in traditional Chinese medicine syndromes， visual analogue scale pain， and laboratory parameters （all P < 0.05）. The hierarchical clinical efficacy of the experimental group was significantly superior to that of the control group （P < 0.001）. There was no statistically significant difference in the incidence of adverse reactions between the two groups （P > 0.05）. Conclusions Xiaozhong Tounong Decoction combined with antibiotics yields favorable clinical outcomes in the treatment of periappendiceal abscess with dampness-heat syndrome. This integrated treatment approach effectively shortens the treatment duration and significantly alleviates clinical symptoms.