论著·临床实践

经皮耳迷走神经电刺激促进腹腔镜肝胆外科术后胃肠功能恢复的随机对照研究

  • 郭晓晓 ,
  • 张心想 ,
  • 李闫 ,
  • 钱隆 ,
  • 程伟 ,
  • 殷琴
展开
  • 1.徐州医科大学附属医院麻醉科
    2.淮安市第一人民医院麻醉科 ;(江苏 淮安 223300 )
    3.徐州医科大学附属医院 疼痛科 江苏 徐州 221006

收稿日期: 2025-12-17

  网络出版日期: 2026-04-29

基金资助

吴阶平医学基金资助项目(320.6750.2024-15-48)

A randomized controlled trial of transcutaneous auricular vagus nerve stimulation to promote gastrointestinal recovery after laparoscopic hepatobiliary surgery

  • Xiaoxiao GUO ,
  • Xinxiang ZHANG ,
  • Yan LI ,
  • Long QIAN ,
  • Wei CHENG ,
  • Qin YIN
Expand
  • 1.Department of Anesthesiology,the Affiliated Hospital of Xuzhou Medical University,Xuzhou 221006,Jiangsu,China
    2.Department of Anesthesiology,Huai’an First People’s Hospital,Huai’an 223300,Jiangsu,China
    3.Department of Pain Treatment,the Affiliated Hospital of Xuzhou Medical University,Xuzhou 221006,Jiangsu,China

Received date: 2025-12-17

  Online published: 2026-04-29

摘要

目的 探讨经皮耳迷走神经电刺激(taVNS)对腹腔镜肝胆外科手术患者术后胃肠功能恢复的影响。 方法 选取择期行腹腔镜肝胆外科手术的患者170例,随机分配至taVNS组(n = 85)和对照组(n = 85)。分别于术前1 d、诱导前30 min、术后入恢复室各接受1次刺激或假刺激,每次刺激30 min。记录患者术后首次排气、排便时间,术后第1、2、3天的进食-恶心-呕吐-查体-症状持续时间评分(I-FEED),术后48 h恶心呕吐发生率,术后拔管即刻及术后第1、2、3天的疼痛数字评分(NRS),术后第1、2、3天的阿森斯失眠量表(AIS)和焦虑抑郁量表(HADS),术后早期恢复质量(QoR-15),术后不良反应发生情况等。 结果 与对照组相比,taVNS组术后首次排气、排便时间明显缩短,术后I-FEED评分降低,拔除气管导管即刻及术后第1天的NRS评分降低,术后48 h恶心呕吐发生率降低,术后第1天的QoR-15评分提升(P < 0.05)。两组术后AIS评分和HADS评分差异无统计学意义(P > 0.05)。 结论 taVNS可改善腹腔镜肝胆外科手术患者术后胃肠功能恢复情况,减轻术后恶心、呕吐,缓解术后疼痛,并促进术后恢复。

本文引用格式

郭晓晓 , 张心想 , 李闫 , 钱隆 , 程伟 , 殷琴 . 经皮耳迷走神经电刺激促进腹腔镜肝胆外科术后胃肠功能恢复的随机对照研究[J]. 实用医学杂志, 2026 , 42(9) : 1649 -1656 . DOI: 10.3969/j.issn.1006-5725.2026.09.021

Abstract

Objective To investigate the impact of transcutaneous auricular vagus nerve stimulation (taVNS) on the postoperative recovery of the gastrointestinal system in patients who have undergone laparoscopic hepatobiliary surgery. Methods A total of 170 patients undergoing elective laparoscopic hepatobiliary surgery were randomly allocated to the taVNS group (n = 85) and the control group (n = 85). Participants received three consecutive 30-minute sessions of active stimulation or sham stimulation at three time points: (1) one day before the operation, (2) 30 minutes before induction, and (3) upon arrival at the recovery room after the operation. The following parameters were recorded: the time to the first postoperative flatus and bowel movement; Intake-Nausea-Emesis-Examination-Duration (I-FEED) scores on the first, second, and third postoperative days; the incidence of nausea and vomiting within 48 hours after the operation; the pain numerical rating scale (NRS) immediately after extubation and on the first, second, and third postoperative days; the Athens Insomnia Scale (AIS) and the Hospital Anxiety and Depression Scale (HADS) on the first, second, and third postoperative days; the early postoperative quality of recovery (QoR-15), and the occurrence of postoperative adverse reactions. Results Compared with the control group, the taVNS group exhibited significantly shorter durations until the first postoperative flatus and bowel movement, a reduction in postoperative I-FEED scores, lower NRS scores immediately after extubation and on postoperative day 1, a decreased incidence of postoperative nausea and vomiting at 48 hours, and an improvement in QoR-15 scores on postoperative day 1 (P < 0.05). No statistically significant differences were detected between the groups in postoperative AIS scores or HADS scores (P > 0.05). Conclusion TaVNS enhances postoperative gastrointestinal recovery in patients undergoing laparoscopic hepatobiliary surgery, mitigates postoperative nausea and vomiting, alleviates postoperative pain, and facilitates recovery.

参考文献

[1] WANG B, HAN D, HU X, et al. Perioperative liberal drinking management promotes postoperative gastrointestinal function recovery after gynecological laparoscopic surgery: A randomized controlled trial[J]. J Clin Anesth, 2024, 97: 111539. doi: 10.1016/j.jclinane.2024.111539 .
[2] 李月, 冯艺, 闫琦. 术后胃肠功能紊乱的临床研究进展[J]. 临床麻醉学杂志, 2022, 38(3): 299-303. doi: 10.12089/jca.2022.03.016 .
[3] VENARA A, NEUNLIST M, SLIM K, et al. Postoperative ileus: Pathophysiology, incidence, and prevention[J]. J Visc Surg, 2016, 153(6): 439-446. doi: 10.1016/j.jviscsurg.2016.08.010 .
[4] KOVOOR J G, STRETTON B, JACOBSEN J H W, et al. Gastrointestinal recovery after surgery: Protocol for a systematic review[J]. BMJ open, 2021, 11(10): e054704. doi: 10.1136/bmjopen-2021-054704 .
[5] ZENG H J, LIU J J, YANG Y C. Clinical observation of gastrointestinal function recovery in patients after hepatobiliary surgery[J]. World J Gastrointest Surg, 2024, 16(1): 76-84. doi: 10.4240/wjgs.v16.i1.76 .
[6] 李偲, 刘克玄, 邓小明, 等. 术后胃肠功能障碍防治专家共识[J]. 国际麻醉学与复苏杂志, 2021, 42(11): 1133-1142. doi: 10.3760/cma.j.cn321761-20210811-10003 .
[7] TEVIS S E, CARCHMAN E H, FOLEY E F, et al. Postoperative ileus--more than just prolonged length of stay?[J]. J Gastrointest Surg, 2015, 19(9): 1684-1690. doi: 10.1007/s11605-015-2877-1 .
[8] 刘超磊, 苑雪娇, 孙章楠, 等. 右美托咪定联合腹横肌平面阻滞对腹腔镜结直肠手术患者术后胃肠道功能的影响[J]. 实用医学杂志, 2021, 37(23): 3026-3030. doi: 10.3969/j.issn.1006-5725.2021.23.013 .
[9] BRAGG D, El-ShARKAWY A M, PSALTIS E, et al. Postoperative ileus: Recent developments in pathophysiology and management[J]. Clin Nutr, 2015, 34(3): 367-376. doi: 10.1016/j.clnu.2015.01.016 .
[10] DRAKE T M, WARD A E. Pharmacological management to prevent ileus in major abdominal surgery: A systematic review and meta-analysis[J]. J Gastrointest Surg, 2016, 20(6): 1253-1264. doi: 10.1007/s11605-016-3140-0 .
[11] WANG Y, DUAN C, DU X, et al. Vagus nerve and gut-brain communication[J]. Neuroscientist, 2025, 31(3): 262-278. doi: 10.1177/10738584241259702 .
[12] HONG G S, ZILLEKENS A, SCHNEIKER B, et al. [J]. Neurogastroenterol Motil, 2019, 31(3): e13501. doi: 10.1111/nmo.13501 .
[13] BONAZ B, SINNIGER V, PELLISSIER S. Anti‐inflammatory properties of the vagus nerve: Potential therapeutic implications of vagus nerve stimulation[J]. J Physiol, 2016, 594(20): 5781-5790. doi: 10.1113/JP271539
[14] WANG Y, LI S Y, WANG D, et al. Transcutaneous auricular vagus nerve stimulation: From concept to application[J]. Neurosci Bull, 2021, 37(6): 853-862. doi: 10.1007/s12264-020-00619-y .
[15] STEIDEL K, KRAUSE K, MENZLER K, et al. Transcutaneous auricular vagus nerve stimulation influences gastric motility: A randomized, double-blind trial in healthy individuals[J]. Brain Stimul, 2021, 14(5): 1126-1132. doi: 10.1016/j.brs.202 1.06.006 .
[16] HUANG C H, WU C H, CHAN R H, et al. Transcutaneous auricular vagus nerve stimulation accelerates postoperative ileus recovery by enhancing gastric motility complexity: A clinical study[J]. Brain Stimul, 2025, 18(4): 1091-1093. doi: 10.1016/j.brs.2025.05.002 .
[17] RU O, JIN X, QU L, et al. Low-intensity transcutaneous auricular vagus nerve stimulation reduces postoperative ileus after laparoscopic radical resection of colorectal cancer: A randomized controlled trial[J]. Minerva Anestesiol, 2023, 89(3):149-156. doi: 10.23736/S0375-9393.22.16735-0 .
[18] VAN BEEKUM C J, WILLIS M A, VON WEBSKY M W, et al. Electrical vagus nerve stimulation as a prophylaxis for SIRS and postoperative ileus[J]. Autonomic Neuroscience, 2021, 235: 102857. doi: 10.1016/j.autneu.2021.102857 .
[19] CLANCY J A, MARY D A, WITTE K K, et al. Non-invasive vagus nerve stimulation in healthy humans reduces sympathetic nerve activity[J]. Brain Stimul, 2014, 7(6): 871-877. doi: 10.1016/j.brs.2014.07.031 .
[20] BARLETTA J F, ASGEIRSSON T, SENAGORE A J. Influence of intravenous opioid dose on postoperative ileus[J]. Ann Pharmacother, 2011, 45(7/8): 916-923. doi: 10.1345/aph.1Q041 .
[21] BABIC T, BROWNING K N. The role of vagal neurocircuits in the regulation of nausea and vomiting[J]. Eur J Pharmacol, 2014, 722: 38-47. doi: 10.1016/j.ejphar.2013.08.047 .
[22] BADRAN B W, DOWDLE L T, MITHOEFER O J, et al. Neurophysiologic effects of transcutaneous auricular vagus nerve stimulation (taVNS) via electrical stimulation of the tragus: A concurrent taVNS/fMRI study and review[J]. Brain Stimul, 2018, 11(3): 492-500. doi: 10.1016/j.brs.2017.12.009 .
[23] ZHANG F C, WENG R X, Li D, et al. A vagus nerve dominant tetra-synaptic ascending pathway for gastric pain processing[J]. Nat Commun, 2024, 15(1): 9824. doi: 10.1038/s41467-024-54056-w .
[24] FORNARO R, ACTIS G C, CAVIGLIA G P, et al. Inflammatory bowel disease: Role of vagus nerve stimulation[J]. J Clin Med, 2022, 11(19): 5690. doi: 10.3390/jcm11195690 .
[25] XIONG X, TAO M, ZHAO W, et al. Transcutaneous auricular vagus nerve stimulation for postpartum contraction pain during elective cesarean delivery[J]. JAMA Netw Open, 2025, 8(8): e2529127. doi: 10.1001/jamanetworkopen.2025.29127 .
[26] YIN Z Y, WANG J, WEI P, et al. Impact of transcutaneous auricular vagus nerve stimulation on postoperative pain in patients undergoing perianal surgery: A randomized trial[J]. Ann Med, 2025, 57(1): 2476045. doi: 10.1080/07853890.2025.2476045 .
[27] 黄豪逊, 王行何, 张妍, 等. 经皮耳迷走神经刺激联合患者静脉自控镇痛对全膝关节置换术患者术后疼痛的影响[J]. 针刺研究, 2025, 50(2): 190-196. doi: 10.13702/j.1000-0607.20231101 .
[28] LIU C, TANG H, LIU C, et al. Transcutaneous auricular vagus nerve stimulation for post-stroke depression: A double-blind, randomized, placebo-controlled trial[J]. J Affect Disord, 2024, 354: 82-88. doi: 10.1016/j.jad.2024.03.005 .
[29] TAN C, QIAO M, MA Y, et al. The efficacy and safety of transcutaneous auricular vagus nerve stimulation in the treatment of depressive disorder: A systematic review and meta-analysis of randomized controlled trials[J]. J Affect Disord, 2023, 337: 37-49. doi: 10.1016/j.jad.2023.05.048 .
[30] ZHANG S, ZHAO Y, QIN Z, et al. Transcutaneous auricular vagus nerve stimulation for chronic insomnia disorder: A randomized clinical trial[J]. JAMA Netw Open, 2024, 7(12): e2451217. doi: 10.1001/jamanetworkopen.2024.51217 .
[31] 孙正秀, 汪媛媛, 林永傲, 等. 经皮耳迷走神经刺激对胸腔镜肺切除术患者术后早期恢复质量的影响[J]. 实用医学杂志, 2025, 41(17): 2670-2675. doi: 10.3969/j.issn.1006-5725.2025.17.009 .
文章导航

/