目的 评估胚胎时差成像技术中的胚胎动力学参数在体外受精-胚胎移植（IVF-ET）助孕患者胚胎着床潜力中的预测价值。 方法 选取南阳市第一人民医院在2022年6月至2024年6月期间因输卵管性不孕行IVF-ET的助孕患者292例作为研究对象，在移植28 d后根据B超检查显示的胚胎着床情况分为着床组103例，未着床组189例，比较各组患者基本资料以及胚胎动力学参数，通过多因素logistic回归分析IVF-ET助孕患者胚胎未着床的高危因素，随后通过受试者工作特征（ROC）曲线评价高危因素对胚胎着床潜力的预测价值。 结果 相较于着床组，未着床组患者的胚胎动力学参数原核消失至2-细胞阶段时间（t2）、原核消失至3-细胞阶段时间（t3）、原核消失至4-细胞阶段时间（t4）、2-细胞分裂至3-细胞的时间（cc2）、3-细胞分裂至4-细胞的时间（s2）、4-细胞分裂至5-细胞的时间（cc3）水平均较高（P < 0.05）。t2（OR = 4.293）、t3（OR = 5.507）、t4（OR = 5.534）、s2（OR = 3.755）是IVF-ET助孕患者胚胎未着床的独立危险因素（P < 0.05）。t2（cut-off值为27.02 h）、t3（cut-off值为39.76 h）、t4（cut-off值为41.95 h）、s2（cut-off值为1.44 h）水平对IVF-ET助孕患者胚胎着床失败的预测效能均较高，曲线下面积（AUC）分别为0.767、0.744、0.720、0.878（P < 0.05），且s2水平预测IVF-ET助孕患者胚胎未着床的效能均高于t2、t3、t4（Z = 3.044、3.563、4.413，P < 0.05）。 结论 胚胎动力学参数t2、t3、t4、s2水平与IVF-ET助孕患者胚胎着床情况密切相关，采取胚胎时差成像技术能够协助医务人员对IVF-ET助孕患者胚胎着床潜力进行预测。

Objective To evaluate the predictive value of embryo dynamics parameters during embryo time-lapse imaging technique on embryo implantation potential in patients receiving in vitro fertilization-embryo transfer （IVF-ET） assisted pregnancy. Methods A total of 292 patients who underwent IVF-ET assisted pregnancy at Nanyang First People's Hospital between June 2022 and June 2024 were selected as study subjects. After 28 days of transplantation， the patients were divided into 103 cases in implantation group and 189 cases in non-implantation group based on the embryo implantation status detected by B-ultrasound. The basic data and embryo dynamics parameters of the patients in each group were compared. Multivariate logistic regression analysis was conducted to identify high-risk factors for embryo non-implantation in patients with IVF-ET assisted pregnancy. Subsequently， the predictive value of these high-risk factors on embryo implantation potential was evaluated by using receiver operating characteristic （ROC） curve. Results Compared with implantation group， the embryo dynamics parameters in non-implantation group were higher， including the time of pronuclear breakdown to 2-cell stage （t2）， time of pronuclear breakdown to 3-cell stage （t3）， time of pronuclear breakdown to 4-cell stage （t4）， time of 2-cell division to 3-cell stage （cc2）， time of 3-cell division to 4-cell stage （s2）， and time of 4-cell division to 5-cell stage （cc3） （P < 0.05）. t2 （OR = 4.293）， t3 （OR = 0.507）， t4 （OR = 5.534） and s2 （OR = 3.755） were independent risk factors for embryo non-implantation in patients with IVF-ET assisted pregnancy （P < 0.05）. t2， t3， t4 and s2 had high predictive efficiency on embryo implantation failure in patients with IVF-ET assisted pregnancy， and their areas under the curves （AUCs） were 0.767， 0.744， 0.720 and 0.878 respectively （P < 0.05）， and the efficiency of s2 in predicting embryo non-implantation in patients with IVF-ET assisted pregnancy was higher than that of t2， t3 or t4 （Z = 3.044， 3.563， 4.413， P < 0.05）. Conclusions The levels of embryo dynamics parameters t2， t3， t4 and s2 are closely related to the embryo implantation in patients with IVF-ET assisted pregnancy. The use of embryo time-lapse imaging technique can assist medical staff in predicting the embryo implantation potential in patients with IVF-ET assisted pregnancy.