收稿日期: 2025-12-17
网络出版日期: 2026-04-28
基金资助
湖北省卫健委科研项目(2025AFD350)
Effect of preoperative ozone joint injection combined with high tibial osteotomy on postoperative functional recovery and inflammatory regulation in patients with knee osteoarthritis
Received date: 2025-12-17
Online published: 2026-04-28
目的 观察术前臭氧注射联合胫骨高位截骨术（HTO）对膝关节骨性关节炎（KOA）患者关节功能、步态恢复及血清炎症因子水平的影响。 方法 回顾性选取2024年3月至2025年3月在黄冈市中心医院进行HTO治疗的KOA患者共93例，根据术前是否进行膝关节臭氧注射分为A组（进行膝关节臭氧注射，n = 47）和B组（未进行膝关节臭氧注射，n = 46）。比较两组治疗前后关节功能［用西安大略和麦克马斯特大学骨关节炎指数（WOMAC）、膝关节功能评分（HSS评分）、胫骨近端内侧角（MPTA）、关节活动范围（ROM）］、步态恢复（步长、步速、步频等步态参数）以及血清白细胞介素（IL）-1β、IL-6、IL-8、IL-10的变化。并观察术后5周、术后1月及6月的膝关节疼痛状况［视觉疼痛模拟评分（VAS）］，记录并发症。 结果 术后5周，A组WOMAC、MPTA均低于B组，HSS评分、ROM均高于B组（P < 0.05）；A组120 m步态检测中的步长、步速、步频均高于B组（P < 0.05）；A组血清IL-1β、IL-6、IL-8水平均低于B组，IL-10水平高于B组（P < 0.05）。A组术后5周、1月及6月的VAS评分均低于B组（P < 0.05）。两组术后并发症发生率比较差异无统计学意义（P > 0.05）。 结论 KAO患者HTO前应用膝关节臭氧注射可有效促进术后关节功能、步态恢复，下调血清炎症反应，减轻术后疼痛。
李小松 , 尹金金 , 桂凯红 , 薛威 , 宋君来 . 术前臭氧关节注射联合胫骨高位截骨术对膝骨关节炎患者术后功能恢复与炎症调控的影响[J]. 实用医学杂志, 2026 , 42(8) : 1361 -1366 . DOI: 10.3969/j.issn.1006-5725.2026.08.008
Objective To observe the effects of preoperative ozone injection combined with high tibial osteotomy （HTO） on joint function， gait recovery， and serum inflammatory factors in patients with knee osteoarthritis （KOA）. Methods A total of 93 patients with KOA who underwent HTO in the hospital were retrospectively enrolled from March 2024 to March 2025. Based on the presence or absence of preoperative knee injection of ozone， they were divided into group A （injection， n = 47） and group B （non-injection， n = 46）. The changes in joint function， including the Western Ontario and McMaster Universities Osteoarthritis Index （WOMAC）， Hospital for Special Surgery Knee Score （HSS score）， medial proximal tibial angle （MPTA）， and range of motion （ROM）， gait recovery （step length， walking speed， stride frequency）， and serum levels of Interleukin （IL）-1β， IL-6， IL-8， and IL-10 before and after treatment were compared between the two groups. Knee pain， as measured by the visual analogue scale （VAS）， was observed at 5 weeks， 1 month， and 6 months after surgery， and complications were recorded. Results At 5 weeks post-surgery， the WOMAC and MPTA in group A were lower than those in group B， whereas the HSS score and ROM were higher than those in group B （P < 0.05）. In the 120-meter gait test， the step length， walking speed， and stride frequency in group A were all higher than those in group B （P < 0.05）. The serum levels of IL-1β， IL-6， and IL-8 in group A were lower than those in group B， and the level of IL-10 was higher than that in group B （P < 0.05）. At 5 weeks， 1 month， and 6 months post-surgery， the Visual Analog Scale （VAS） scores in group A were lower than those in group B （P < 0.05）. There was no significant difference in the incidence of postoperative complications between the two groups （P > 0.05）. Conclusion Intra-knee injection of ozone can effectively promote the postoperative recovery of joint function and gait， alleviate the serum inflammatory response， and relieve postoperative pain in patients with KAO before HTO.
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