目的 分析小于32周早产儿颅内出血与凝血功能、血小板计数的相关性。 方法 选择2020年5月至2024年7月安徽医科大学附属阜阳人民医院收治的101例小于32周早产儿，出生3 d内，所有患儿均根据小于32周早产儿是否发生颅内出血分为非发生组（59例）、发生组（42例）。比较发生组与非发生组的临床资料、凝血功能及血小板计数。分析小于32周早产儿发生颅内出血的影响因素。分析凝血功能指标、血小板计数对小于32周早产儿发生颅内出血的预测价值。 结果 发生组出生体质量、胎龄低于非发生组（P < 0.05）。发生组纤维蛋白原（FIB）、D-二聚体（D-D）高于非发生组（P < 0.05），发生组凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）长于非发生组（P < 0.05），发生组血小板计数低于非发生组（P < 0.05）。FIB（OR = 4.272，95%CI：2.154 ~ 8.472）、D-D（OR = 3.607，95%CI：1.819 ~ 7.155）、APTT（OR = 3.056，95%CI：1.541 ~ 6.060）为小于32周早产儿发生颅内出血的独立危险因素（P < 0.05），血小板计数（OR = 0.282，95%CI：0.142 ~ 0.560）为小于32周早产儿发生颅内出血的保护因素（P < 0.05）。FIB、D-D、APTT、血小板计数及四者联合预测小于32周早产儿发生颅内出血的AUC值分别为0.799、0.803、0.845、0.796、0.911（P < 0.05），且四者联合的AUC值更高（P < 0.05）。 结论 FIB、D-D、APTT、血小板计数在预测小于32周早产儿发生颅内出血中具有重要价值，且四者联合的预测价值更高。

Objective To analyze the correlation between intracranial hemorrhage and coagulation function， platelet count in preterm infants younger than 32 weeks. Methods A total of 101 preterm infants under 32 weeks who were admitted to Fuyang People's Hospital Affiliated to Anhui Medical University from May 2020 to July 2024 were selected. Within 3 days after birth， all the children were divided into the non-occurrence group （59 cases） and the occurrence group （42 cases） based on whether intracranial hemorrhage occurred in preterm infants less than 32 weeks.The influencing factors of intracranial hemorrhage in preterm infants less than 32 weeks was analyzed. he predictive value of coagulation function index and platelet count for intracranial hemorrhage in preterm infants less than 32 weeks was analyzed. Results The birth weight and gestational age of the occurrence group were lower than non-occurrence group （P < 0.05）.Fibrinogen （FIB） and D-dimer （D-D） in the occurrence group were higher than non-occurrence group （P < 0.05）， and the prothrombin time （PT） and activated partial thromboplastin time （APTT） in the occurrence group were longer than non-occurrence group （P < 0.05）， and platelet count in occurrence group was lower than non-occurrence group （P < 0.05）. FIB （OR = 4.272， 95%CI： 2.154 ? 8.472）， D-D （OR = 3.607， 95%CI： 1.819 ? 7.155）， APTT （OR = 3.056， 95%CI： 1.541 ? 6.060） was an independent risk factor for intracranial hemorrhage in preterm infants less than 32 weeks （P < 0.05）， and platelet count （OR = 0.282， 95%CI： 0.142 ? 0.560） was a protective factor for intracranial hemorrhage in preterm infants less than 32 weeks （P < 0.05）. The AUC values of FIB， D-D， APTT， platelet count and the combined prediction of intracranial hemorrhage in preterm infants less than 32 weeks were 0.799， 0.803， 0.845， 0.796 and 0.911， respectively （P < 0.05）， and the AUC values of the combined four groups were higher （P < 0.05）. Conclusion FIB， D-D， APTT and platelet count have important value in predicting intracranial hemorrhage in preterm infants less than 32 weeks， and the combined value of the four is higher.