收稿日期: 2025-11-08
网络出版日期: 2026-03-09
基金资助
吴阶平医学基金会项目(320.6750.2024-03.21);广州市科学技术局市校院（企）联合项目(2025A03J3160);广州医科大学科研强基项目(2025SRP030)
Consensus on integrative medicine cooling therapy management during the peri-chemotherapy period for breast cancer
乳腺癌是全球女性最常见的恶性肿瘤之一，化疗作为乳腺癌治疗的其中一项重要手段，常伴随许多副作用，如脱发、手足综合征等，甚至进一步严重影响患者心理状态和生活质量。针对这一问题，研究表明采用冰冻治疗可有效降低脱发率，但仍有16% ~ 84%患者脱发。临床应用发现乳腺癌患者化疗过程中配合中医药治疗，可进一步降低脱发率、手足综合征发生率，缓解患者痛苦，提高生活质量，还有化疗增敏、增效的作用。但在实际应用中存在标准不一的问题，为进一步规范、指导临床实践，特邀乳腺肿瘤学、中医肿瘤学、护理学等多领域专家进行多轮研讨，最终形成本共识。本共识将从范围、术语和定义、理论基础、实施规范、中医特色疗法、疗效评价等方面对中西医结合冰冻治疗管理进行规范。重点围绕中西医结合冰冻治疗管理化疗中的实施规范、中医特色疗法进行论述，共提出7条推荐意见，以期为临床实践提供规范化指引。
关键词： 乳腺癌; 化疗所致脱发; 手足综合征; 中西医结合冰冻治疗管理; 共识
林欢 , 李洪胜 , 黄梅 , 张国淳 , 王能 , 黄冠群 , 许娟 , 邹青峰 , 石兴源 , 何文广 , 李锋 , 蔡延庆 , 黄晓平 , 黄琼刁 , 杨泽娟 , 罗润妹 , 张洁文 , 唐毅 , 许朝亮 , 高红飞 , 陈伟财 , 胡灏 , 姚勇生 , 黄楚 , 黄杰文 , 黄毅超 , 雷叶雁 , 罗明 , 吴哲 , 袁南贵 , 林泳婷 . 乳腺癌围化疗期中西医结合冰冻治疗管理专家共识[J]. 实用医学杂志, 2026 , 42(5) : 723 -733 . DOI: 10.3969/j.issn.1006-5725.2026.05.001
Breast cancer stands as one of the most prevalent malignant tumors among women globally. Chemotherapy， being a crucial element in breast cancer treatment， is frequently linked to diverse side-effects， including alopecia and hand-foot syndrome. These adverse reactions can significantly undermine patients' psychological health and quality of life. In response to this issue， international research has indicated that cooling therapy can effectively decrease the incidence of alopecia； however， 16% to 84% of patients still encounter hair loss. Clinical practice has proven that combining traditional Chinese medicine with chemotherapy in breast cancer treatment can further reduce the incidence of alopecia and hand-foot syndrome， relieve patient discomfort， improve the quality of life， and offer chemosensitizing and efficacy-enhancing effects. Nevertheless， there is a deficiency of standardized protocols in practical applications. To further standardize and optimize clinical practice， a multidisciplinary expert panel consisting of breast oncology specialists， oncological traditional Chinese medicine experts， and nursing science professionals was assembled. After multiple rounds of deliberation and revision， this consensus document was finally formulated. This consensus standardizes Integrative Medicine Cooling Therapy Management from multiple perspectives， such as scope， terminology and definitions， theoretical bases， implementation procedures， characteristic TCM therapies， and efficacy assessment. It especially emphasizes the implementation procedures during chemotherapy and characteristic TCM treatment methods. The document puts forward seven evidence-based recommendations to offer standardized guidance for clinical practice.
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