目的 探讨针灸治疗在缺血性脑卒中康复患者免疫稳态重建、炎症指标和患者日常生活能力改善中的价值。 方法 本研究为单中心随机对照临床研究，选取2023年8月至2025年1月就诊于医院的100例缺血性脑卒中康复患者入组，按照随机数字表法分为两组，其中康复对照组50例给予中西医康复综合治疗，针灸试验组50例实施针灸联合中西医康复综合治疗，比较各组治疗前后的免疫细胞、炎性指标水平以及Barthel指数和Fugl-Meyer运动功能评定量表变化情况。另选取同时期健康体检人群50例为健康参照组。 结果 康复对照组和针灸试验组患者的总T淋巴细胞、T辅助/调节淋巴细胞（CD4⁺T细胞）、T抑制/细胞毒淋巴细胞（CD8⁺T细胞）水平均明显低于健康参照组，而B细胞、NK细胞水平均高于健康参照组，两组间差异有统计学意义（P < 0.05）。治疗后针灸试验组患者的总T细胞、CD4⁺T细胞、CD4⁺/CD8⁺升高水平均明显高于康复对照组，B细胞和NK细胞降低水平均明显高于康复对照组；治疗后两组患者炎症指标水平较治疗前均有所降低，针灸试验组下降幅度明显高于康复对照组。治疗后针灸试验组与康复对照组Barthel指数水平和Fugl-Meyer运动功能评定量表评分均有所上升，且针灸试验组高于康复对照组，差异有统计学意义（P < 0.05）。针灸试验组总体疗效优于康复对照组，总体有效率分别为96.00%和72.00%，差异有统计学意义（P < 0.05），两组患者不良反应发生率比较差异无统计学意义。 结论 针灸在缺血性脑卒中康复治疗中可以显著改善免疫状态、降低炎症指标和提高日常生活能力。

Objective To investigate the value of acupuncture therapy in restoring immune homeostasis， reducing the levels of inflammatory markers， and improving the activities of daily living in patients recovering from ischemic stroke. Methods This research is a single-center， randomized controlled clinical trial. A total of 100 patients with ischemic stroke who were undergoing rehabilitation between August 2023 and January 2025 were enrolled. By using a random number table， the participants were randomly allocated to either a rehabilitation control group （n = 50）， which received integrated Chinese-Western rehabilitation therapy， or an acupuncture experimental group （n = 50）， which received acupuncture in addition to the standard integrated rehabilitation. The immune parameters （T， B， NK cell counts and CD4⁺/CD8⁺ ratio）， inflammatory markers， Barthel Index （BI）， and Fugl-Meyer Assessment （FMA） scores were compared before and after treatment. A cohort of 50 healthy individuals served as the healthy control group for assessing the baseline immune and inflammatory status. Results At baseline， the patient groups exhibited significant immune dysregulation when compared to the healthy control group. This was manifested by lower counts of total T cells， CD4⁺ cells， and CD8⁺ cells， as well as higher levels of B cells and NK cells （P < 0.05）. After the intervention， the acupuncture experimental group demonstrated a substantial increase in total T cells， CD4⁺ cells， and the CD4⁺/CD8⁺ ratio. Moreover， there was a more marked reduction in B and NK cell levels in the acupuncture experimental group compared to the rehabilitation control group. Inflammatory markers decreased in both groups after treatment， but the reduction amplitude was significantly greater in the acupuncture experimental group. Similarly， although both groups exhibited enhanced BI and FMA scores before and after treatments， the improvements were statistically more significant in the acupuncture experimental group （P < 0.05）. The acupuncture group showed significantly higher overall therapeutic efficacy compared to the rehabilitation control group， with overall therapeutic efficacy rates of 96.0% and 72.0%， respectively （P < 0.05）. There was no significant difference in the incidence of adverse reactions between the two groups. Conclusion Adjunctive acupuncture significantly promotes immune rebalancing， alleviates inflammation， and enhances functional independence in rehabilitation patients with ischemic stroke.