收稿日期: 2025-10-13
网络出版日期: 2026-01-14
基金资助
河南省医学科技攻关计划项目(LHGJ20230891)
Predictive value of yolk sac size morphology and inner diameter changes in early pregnancy on early abortion
Received date: 2025-10-13
Online published: 2026-01-14
目的 分析妊娠早期阶段卵黄囊大小形态学及内径变化对早期流产的预测价值。 方法 选择2023年1月至2024年12月医院收治的120例早期妊娠孕妇作为研究对象（最终纳入118例，失访2例），根据妊娠结局分成正常妊娠组（n = 82）和早期流产组（n = 36）。比较两组基线资料、卵黄囊参数，采用多因素logistic回归分析影响早期流产的危险因素，并通过ROC曲线评估妊娠早期阶段卵黄囊大小形态学及内径变化对早期流产的预测价值。 结果 早期流产组年龄≥ 35岁比例显著高于正常妊娠组（P < 0.05）；早期流产组各孕周的卵黄囊直径显著大于正常妊娠组（P < 0.05）；早期流产组卵黄囊缺失比例、卵黄囊直径异常比例、卵黄囊形状异常比例均显著高于正常妊娠组（P < 0.05）；多因素logistic回归分析显示，年龄≥ 35岁（OR = 1.664，95%CI：1.272 ~ 2.176）、卵黄囊缺失（OR = 23.927，95%CI：9.561 ~ 59.876）、卵黄囊直径异常（OR = 30.114，95%CI：13.092 ~ 69.269）、卵黄囊形状异常（OR = 16.844，95%CI：6.359 ~ 44.617）是影响早期流产的危险因素；ROC曲线分析显示，卵黄囊形状异常预测早期流产的价值最高（AUC = 0.862），其次为卵黄囊直径异常（AUC = 0.669）、卵黄囊缺失（AUC = 0.611）。 结论 妊娠早期卵黄囊形状异常可作为预测早期流产的重要指标，为早期干预提供科学依据。
魏景蕊 , 刘巧方 , 李友云 , 王珊 , 徐帅 . 妊娠早期阶段卵黄囊大小形态学及内径变化对早期流产的预测价值[J]. 实用医学杂志, 2026 , 42(1) : 152 -156 . DOI: 10.3969/j.issn.1006-5725.2026.01.020
Objective To analyze the predictive value of yolk sac size morphology and inner diameter changes in early pregnancy on early abortion. Methods A total of 120 pregnant women with early pregnancy admitted to the hospital from January 2023 to December 2024 were selected as research subjects （118 cases were finally included and 2 cases were lost to follow-up）. According to the pregnancy outcomes， they were divided into normal pregnancy group （n = 82） and early abortion group （n = 36）. Baseline data and yolk sac parameters were compared between the two groups. Multivariate Logistic regression analysis was used to analyze the risk factors affecting early abortion， and ROC curve was used to evaluate the predictive value of yolk sac size morphology and inner diameter changes in early pregnancy on early abortion. Results The proportion of age ≥ 35 years old in early abortion group was significantly higher than that in the normal pregnancy group （P < 0.05）. The yolk sac diameter of each gestational week in early abortion group was significantly larger than that in normal pregnancy group （P < 0.05）. The proportion of yolk sac deletion， proportion of abnormal yolk sac diameter and proportion of abnormal yolk sac morphology were significantly higher in early abortion group than those in normal pregnancy group （P < 0.05）. Multivariate Logistic regression analysis showed that age ≥ 35 years old （OR = 1.664， 95%CI： 1.272 ~ 2.176）， yolk sac deletion （OR = 23.927， 95% CI： 9.561 ~ 59.876）， abnormal yolk sac diameter （OR = 30.114， 95%CI： 13.092 ~ 69.269） and abnormal yolk sac morphology （OR = 16.844， 95% CI： 6.359 ~ 44.617） were risk factors for early abortion. ROC curve analysis showed that the abnormal yolk sac morphology had the highest value on predicting early abortion （AUC = 0.862）， followed by abnormal yolk sac diameter （AUC = 0.669） and yolk sac deletion （AUC = 0.611）. Conclusion The abnormal morphology of yolk sac in early pregnancy can be used as an important indicator to predict early abortion and provide scientific basis for early intervention.
Key words： early abortion; yolk sac; morphology; early pregnancy; predictive value
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