收稿日期: 2025-09-10
网络出版日期: 2025-12-18
基金资助
国家自然科学基金资助项目(82060876);国家自然科学基金资助项目(82360942)
Research progress on the treatment of femoral skull necrosis by extracellular vesicles from bone marrow mesenchymal stem cells
Received date: 2025-09-10
Online published: 2025-12-18
李爱强 , 赵宁 , 张旭升 , 柳海平 . 骨髓间充质干细胞来源细胞外囊泡治疗股骨头骨坏死的研究进展[J]. 实用医学杂志, 2025 , 41(23) : 3631 -3637 . DOI: 10.3969/j.issn.1006-5725.2025.23.001
Osteonecrosis of the femoral head （ONFH） is a disabling orthopedic disease， pathologically characterized by progressive collapse of the femoral head accompanied by destruction of the trabecular and articular cartilage structures， leading to hip joint pain and progressive functional impairment. Bone marrow mesenchymal stem cell-derived extracellular vesicles （BMSC-EVs） show great promise in tissue repair and regeneration， with low immunogenicity and tumorigenicity， and play roles in osteogenesis， angiogenesis， and immunomodulation. This review summarizes the therapeutic effects and underlying mechanisms of BMSC-EVs in ONFH， providing a theoretical basis for its treatment.
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