收稿日期: 2025-07-09
网络出版日期: 2025-11-05
基金资助
广东省中医药局科研项目(20233024)
Effect of Zishen Anshen Tang combined with growth hormone on clinical outcomes of in vitro fertilization embryo transfer in patients with decreased ovarian reserve function
Received date: 2025-07-09
Online published: 2025-11-05
目的 探究滋肾安神汤联合生长激素对卵巢储备功能减退（DOR）患者体外受精-胚胎移植（IVF-ET）临床结局的影响。 方法 选取深圳中山妇产医院生殖中心2023年1月至2024年8月行IVF-ET的DOR患者108例进行临床试验，按照随机数表法分为对照组、观察组各54例。对照组给予生长激素（GH），观察组联合给予滋肾安神汤，比较两组的促排卵情况、扳机日性激素水平、取卵及胚胎情况及临床结局。 结果 两组的促性腺激素（Gn）使用天数差异无统计学意义（P > 0.05）；观察组的Gn用量、早发LH峰率、黄体生成素（LH）小于对照组，雌二醇（E2）、孕酮（P）、获卵数、2PN受精数、可利用胚胎数、第3天的优质胚胎数、囊胚形成率、临床妊娠率、累积妊娠率大于对照组，周期取消率小于对照组（P < 0.05）。 结论 滋肾安神汤联合生长激素用于DOR患者IVF-ET能够改善患者性激素水平，对临床结局产生积极影响。
李瑄 , 林蓉 , 苏嘉文 , 叶敦敏 . 滋肾安神汤联合生长激素对卵巢储备功能减退患者体外受精-胚胎移植临床结局的影响[J]. 实用医学杂志, 2025 , 41(20) : 3283 -3287 . DOI: 10.3969/j.issn.1006-5725.2025.20.019
Objective To investigate the effect of joint of Zishen Anshen Tang and growth hormone on the clinical outcomes of in vitro fertilization embryo transfer （IVF-ET） in patients with decreased ovarian reserve function （DOR）. Methods A clinical trial was conducted on 108 DOR patients who underwent IVF-ET at the Reproductive Center of from January 2023 to August 2024. They were randomly assigned to a control group and a experimental group， each with 54. The control group was given growth hormone （GH）， while the experimental group was additionally given Zishen Anshen Tang. The ovulation induction status， trigger day hormone levels， egg retrieval and embryo development， and clinical outcomes were compared. Results The duration of gonadotropin （Gn） use showed no great difference between two groups （P>0.05）. The experimental group had lower Gn dosage， early LH peak rate， and luteinizing hormone （LH）， higher estradiol （E2）， progesterone （P）， egg retrieval， 2PN fertilization， available embryos， number of high-quality embryos on day 3， blastocyst formation rate， clinical pregnancy rate， and cumulative pregnancy rate， and a lower cycle cancellation rate than control group （P<0.05）. Conclusion The joint of Zishen Anshen Tang and growth hormone for IVF-ET in DOR patients can improve their sex hormone and have a positive impact on clinical outcomes.
| [1] | JIAO X， MENG T， ZHAI Y， et al. Ovarian Reserve Markers in Premature Ovarian Insufficiency： Within Different Clinical Stages and Different Etiologies［J］. Front Endocrinol （Lausanne）， 2021， 12： 601752. doi:10.3389/fendo.2021.601752 |
| [2] | SHOARISHOAR S S， KABOODMEHR R， FAKOR F， et al. Assessment of decreased ovarian reserve and systemic inflammatory markers［J］. Cell Mol Biol （Noisy-le-grand）， 2024， 70（11）： 144-149. doi:10.14715/cmb/2024.70.11.21 |
| [3] | 全松， 王哲. 重视体外受精-胚胎移植反复种植失败的规范化诊治［J］. 实用医学杂志， 2023， 39（21）： 2693-2697. |
| [4] | CHEN J， KONG X， LUAN Z， et al. The effects of growth hormone on the outcomes of in vitro fertilization and embryo transfer in age-grouped patients with decreased ovarian reserve： A prospective cohort study［J］. Front Endocrinol （Lausanne）， 2025， 15： 1457866. doi:10.3389/fendo.2024.1457866 |
| [5] | PARIKN F R， UTTAMCHANDANI S， SAWKAR S， et al. The impact of follicular fluid phthalate metabolites on the ovarian reserve and ovarian function in Indian women undergoing intracytoplasmic sperm injection［J］. F S Sci， 2024， 5（2）： 107-120.. doi:10.1016/j.xfss.2023.11.001 |
| [6] | QIN X， DU J， HE R， et al. Adverse effects of type 2 diabetes mellitus on ovarian reserve and pregnancy outcomes during the assisted reproductive technology process［J］. Front Endocrinol （Lausanne），2023， 14： 1274327. doi:10.3389/fendo.2023.1274327 |
| [7] | 卵巢储备功能减退临床诊治专家共识专家组， 中华预防医学会生育力保护分会生殖内分泌生育保护学组. 卵巢储备功能减退临床诊治专家共识［J］. 生殖医学杂志， 2022， 31（4）： 425-434. |
| [8] | ZHANG Q L， LEI Y L， DENG Y， et al. Treatment Progress in Diminished Ovarian Reserve： Western and Chinese Medicine［J］. Chin J Integr Med， 2023， 29（4）： 361-367. doi:10.1007/s11655-021-3353-2 |
| [9] | AIBORZI S， MADADI G， SAMSAMI A， et al. Decreased ovarian reserve： Any new hope？［J］.Minerva Ginecol， 2015， 67（2）： 149-167. |
| [10] | LELE P R， NAGARAJA N， SINGH Y， et al. Characteristics of Empty Follicular Syndrome during In vitro Fertilization Embryo Transfer and its Association with Various Etiologies in Comparatively Young Patients［J］. J Hum Reprod Sci， 2020， 13（1）： 51-55. doi:10.4103/jhrs.jhrs_96_19 |
| [11] | 王世铭， 祁琳， 刘亚平， 等.内膜厚度与体外受精-胚胎移植妊娠结局的研究进展［J］.实用医学杂志， 2023， 39（21）： 2698-2703. |
| [12] | DUAN W， CHENG Y. Sequential therapy for kidney-tonifying via traditional Chinese medicine effectively improves the reproductive potential and quality of life of women with decreased ovarian reserve： A randomized controlled study［J］. Am J Transl Res， 2021， 13（4）： 3165-3173. |
| [13] | LI H X， SHI L， LIANG S J， et al. Moxibustion alleviates decreased ovarian reserve in rats by restoring the PI3K/AKT signaling pathway［J］. J Integr Med， 2022， 20（2）： 163-172. doi:10.1016/j.joim.2022.01.007 |
| [14] | ZHANG X， ZHANG N， DONG Z， et al. The role of Chinese herbal medicine in diminished ovarian reserve management［J］. J Ovarian Res， 2025， 18（1）： 90. doi:10.1186/s13048-025-01669-4 |
| [15] | LIU Y， WEI M， DENG Y， et al. Advances in Traditional Chinese Medicine for Managing Diminished Ovarian Reserve： Mechanisms and Clinical Insights［J］. Drug Des Devel Ther， 2025， 19： 5597-5614. doi:10.2147/dddt.s505689 |
| [16] | LV Z， LV Z， SONG L， et al. Role of lncRNAs in the pathogenic mechanism of human decreased ovarian reserve［J］. Front Genet， 2023， 14： 1056061. doi:10.3389/fgene.2023.1056061 |
| [17] | KARAKAS E， YAVUZ A， KARAKAS E， et al. Impact of mRNA and Inactivated COVID-19 Vaccines on Ovarian Reserve［J］. Vaccines （Basel）， 2025， 13（4）： 345. doi:10.3390/vaccines13040345 |
| [18] | SCANTAMBURLO V M， LINSINGEN R V， CENTA L J R， et al. Association between decreased ovarian reserve and poor oocyte quality［J］. Obstet Gynecol Sci， 2021， 64（6）： 532-539. doi:10.5468/ogs.20168 |
| [19] | FOULON A， RICHARD N， GUICHARD C， et al. Factors associated with decreased ovarian reserve in Crohn's disease： A systematic review and meta-analysis［J］. Acta Obstet Gynecol Scand， 2024， 103（9）： 1714-1721. doi:10.1111/aogs.14853 |
| [20] | éLISA M， KONYA M， KEKK Z， et al. Platelet-rich plasma （PRP） treatment of the ovaries significantly improves fertility parameters and reproductive outcomes in diminished ovarian reserve patients： A systematic review and meta-analysis［J］. J Ovarian Res， 2024， 17（1）： 104. doi:10.1186/s13048-024-01423-2 |
| [21] | LIN G， LIU X， CONG C， et al. Clinical efficacy of acupuncture for diminished ovarian reserve： A systematic review and meta-analysis of randomized controlled trials［J］. Front Endocrinol， 2023， 14： 1136121. doi:10.3389/fendo.2023.1136121 |
| [22] | QI Q， ZHANG X， YAO L， et al. Pueratin improves diminished ovarian reserve by inhibiting apoptosis［J］. Exp Ther Med， 2021， 22（6）： 1423. doi:10.3892/etm.2021.10858 |
| [23] | 王莉娜，赵艳，于文竹， 等. 卵巢囊肿剥除术对卵巢储备功能及辅助生殖治疗的影响［J］. 中华妇产科杂志， 2023， 58（2）： 98-104. |
| [24] | WU M， ZHU Q， HUANG Y， et al. Ovarian reserve in reproductive-aged patients with cancer before gonadotoxic treatment： A systematic review and meta-analysis［J］. Hum Reprod Open， 2023， 2023（3）： hoad024. doi:10.1093/hropen/hoad024 |
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