目的 探讨XRCC1和XRCC3基因多态性与高危HPV感染人群宫颈癌易感性之间的关联。 方法 选取2021年1月至2023年1月在喀什地区第一人民医院诊断的高危HPV感染宫颈癌患者 176 例作为观察组，高危HPV未患宫颈癌的女性177例作为对照组。对所有参与者进行随访，并对其基因型和HPV型进行检测和分析。 结果 XRCC1 Arg399Gln基因型与特定HPV类型（如16、18、52、58）感染宫颈癌的风险有显著相关性，但与感染的HPV种类数量无显著相关性。研究显示，携带XRCC1 Arg399Gln基因型的个体患宫颈癌的风险比非携带者高，尤其是在HPV16、18、52、58阳性的情况下。XRCC1 Arg280His（P < 0.001）、XRCC3 Thr241Met（P < 0.05）基因型在对照组与宫颈癌组间差异均有统计学意义，而XRCC1 Arg194Trp和XRCC1 Arg399Gln基因型差异无统计学意义（P > 0.05）。XRCC1 Arg280His 多态性分析提示罹患宫颈癌风险显著增加3.57倍（OR = 3.57，95%CI：1.99~6.43），而XRCC1Arg194Trp与罹患宫颈癌风险相关性无统计学意义（P > 0.05）。此外，XRCC1 Arg399Gln（OR = 0.57，95%CI：0.34 ~ 0.96）和XRCC3 Thr241Met（OR = 0.22，95%CI：0.06 ~ 0.84）显示罹患宫颈癌风险显著降低，。 结论 在喀什地区HPV感染人群中，XRCC1 Arg280His多态性显著增加宫颈癌风险，XRCC3 Thr241Met（GG）基因型具有保护效应，而XRCC1 Arg399Gln的保护效应与特定基因型（TT）相关。XRCC1 Arg194Trp与易感性无显著关联。

Objective To investigate the potential association between XRCC1 and XRCC3 gene polymorphisms and susceptibility to cervical cancer within populations infected with high-risk human papillomavirus （HPV）. Methods A cohort of 176 cervical cancer patients with high-risk HPV infection， diagnosed at the First People's Hospital of Kashgar Region between January 2021 and January 2023， were enrolled as the study group. Concurrently， 177 women infected with high-risk HPV but without cervical cancer were enrolled as the control group. All participants were followed up， and genotyping along with HPV subtyping was conducted for subsequent analysis. Results The XRCC1 Arg399Gln genotype showed a significant association with cervical cancer risk among individuals infected with specific HPV subtypes （e.g.， HPV-16， -18， -52， and -58）， but no significant correlation was observed with the number of concurrent HPV infections. Compared to non-carriers， individuals carrying the XRCC1 Arg399Gln genotype exhibited an increased risk of cervical cancer， particularly among those infected with HPV-16， -18， -52， or -58. Statistically significant differences were found between the control group and the cervical cancer group for the XRCC1 Arg280His （P < 0.001） and XRCC3 Thr241Met （P < 0.05） genotypes； however， no significant differences were observed for XRCC1 Arg194Trp and XRCC1 Arg399Gln polymorphisms （P > 0.05）. Further analysis revealed that the XRCC1 Arg280His polymorphism was associated with a 3.57-fold higher risk of cervical cancer （OR = 3.57， 95%CI： 1.99 ~ 6.43）， while XRCC1 Arg194Trp showed no significant association （P > 0.05）. Additionally， XRCC1 Arg399Gln was associated with a reduced risk （OR = 0.57， 95%CI： 0.34 ~ 0.96）， and XRCC3 Thr241Met was linked to a decreased risk of cervical cancer （OR = 0.22， 95%CI： 0.06 ~ 0.84）. Conclusions In the HPV-infected population of Kashgar， the XRCC1 Arg280His polymorphism is significantly associated with an increased risk of cervical cancer （OR = 3.57）， whereas the XRCC3 Thr241Met （GG） genotype exhibits a protective effect （OR = 0.16）. The XRCC1 Arg399Gln variant demonstrates a protective association specifically among TT homozygotes （OR = 0.57）. In contrast， the XRCC1 Arg194Trp polymorphism does not show a statistically significant association with cervical cancer risk.