1 河南科技大学临床医学院，河南科技大学第一附属医院开元院区麻醉科（河南洛阳 471003）；2 河南科技 大学临床医学院，河南省肿瘤表观遗传重点实验室（河南洛阳 471003）
网络出版日期: 2021-03-10
基金资助
河 南 省 医 学 科 技 攻 关 计 划 联 合 共 建 项 目 （2018020303）
Inhibitive effect of propofol on proliferation，migration and invasion of ovarian cancer SKOV3 cells in vitro by down⁃regulating expression of yes⁃associated protein
Clinical Medical Collage of He′nan University of Science and Tech⁃ nology；*Department of Anesthesiology，Kaiyuan Branch of the First Affiliated Hospital of He′nan University of Sci⁃ ence and Technology，Luoyang 471003，China
Online published: 2021-03-10
柏效治 谢小娟 原翔 刘怡文 孔金玉 孙蔚 李燕乐
.
丙泊酚通过下调Yes相关蛋白的表达抑制卵巢癌SKOV3细胞体外的增殖、迁移及侵袭
Objective To investigate the effects of propofol on the proliferation，migration and invasion of ovarian cancer SKOV3 cells. Methods SKOV3 cells were divided into blank control group，solvent control group，25 μmol/L propofol group，50 μmol/L propofol group and 100 μmol/L propofol group. Immunofluorescence assay and Western blot were used to detect the effect of propofol on the expression of yes associated protein（Yap） in SKOV3 cells. Whether Yap over⁃expression interfered with the inhibitory effect of propofol on proliferation ， migration and invasion of SKOV3 cells was observed. Results Propofol inhibited the proliferation，migration and invasion of ovarian cancer SKOV3 cells；Propofol down regulated the expression of Yap protein in the nucleus of SKOV3 cells and Yap overexpression interfered with the inhibitory effect of propofol on the proliferation，migration and invasion of SKOV3 cells. Conclusion propofol may inhibit the proliferation，migration and invasion of SKOV3 cells by down regulating the expression of Yap protein.
/
| 〈 |
|
〉 |