收稿日期: 2025-07-25
网络出版日期: 2025-09-05
The new role of lifestyle interventions in the clinical prevention and treatment of type 2 diabetes
Received date: 2025-07-25
Online published: 2025-09-05
2型糖尿病（diabetes mellitus type 2， T2DM）的患病人数正随着肥胖发病率的逐年递增而快速增加，对全球医疗系统造成严重负担。近年来，生活方式干预（lifestyle intervention， LSI）通过有效减重实现T2DM防治的潜能被发掘，其在临床防治T2DM的重要性与日俱增，但要实现有效的LSI防治T2DM从理论到临床应用的跨越，仍面临着诸多挑战，例如缺乏专业指导、患者依从性差及体质量反弹等问题。尽管如此，鉴于LSI在T2DM防治领域、众多循证医学研究结果的卓越表现以及理论上的可行性，从“以药为主”到“以LSI为主”的理念转变为临床上T2DM的防治带来了新的希望与挑战。
宁潇雨 , 陈小燕 . 生活方式干预在2型糖尿病临床防治中的新角色[J]. 实用医学杂志, 2025 , 41(17) : 2611 -2616 . DOI: 10.3969/j.issn.1006-5725.2025.17.001
The number of patients with type 2 diabetes （T2DM） is rapidly increasing with the annual rise in obesity rates， placing a serious burden on healthcare systems worldwide. In recent years， the potential of lifestyle interventions（LSI） to prevent and treat T2DM through effective weight loss has been recognized， and their importance in the clinical prevention and treatment of T2DM has grown. However， there are still many challenges to be overcome in order to achieve effective LSI prevention and control of T2DM， from theory to clinical application， including a lack of professional guidance， poor patient compliance， and weight regain. Nevertheless， given the outstanding results of numerous evidence-based medical studies on lifestyle interventions in the prevention and treatment of T2DM， as well as their theoretical feasibility，the shift from a “drug-centric” to an “LSI-centric” bringing new hope and new challenges to the clinical prevention and treatment of T2DM.
Key words： lifestyle Intervention; Type 2 diabetes; weight loss
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