目的 回顾性评价针刺会阴穴联合清毒洗液治疗高危型HPV（HR-HPV）持续感染的临床效果。 方法 研究纳入2022年1月至2024年6月期间于广东省中医院大学城医院妇科门诊首次就诊，且确诊为高危型人乳头瘤病毒（HR-HPV）持续感染的患者 264 例。分为观察组和对照组：观察组选用针刺会阴穴联合清毒洗液治疗措施共134例；对照组不采取治疗措施共130例。疗程3个月，分别随访3、6个月，探讨观察组临床疗效及安全性，以及随访对照组的结局。 结果 观察组的HR-HPV转阴率在治疗3个月和6个月后分别为61.9%和65.7%，显著高于对照组的16.9%和21.5%，差异有统计学意义（P < 0.001）；HR-HPV的阳性转化情况在治疗3个月后优于对照组，差异有统计学意义（P < 0.001）；观察组的中医证候疗效高于对照组，差异有统计学意义（P < 0.05）；观察组在随访期间未发现复发病例，对照组复发率为1.5%。治疗期间，观察组患者均无不良反应报告。 结论 针刺会阴穴联合清毒洗液可以提高HR-HPV持续感染治疗效果，且安全性好。

Objective To retrospectively assess the clinical efficacy of acupuncture at the Huiyin point combined with Qingdu wash solution in the treatment of high-risk HPV infection. Methods A total of 264 patients who were initially diagnosed with high-risk HPV infection at the University City Gynecology Department of Guangdong Provincial Hospital of Traditional Chinese Medicine between January 2022 and June 2024 were enrolled in the study. These patients were divided into two groups based on predefined inclusion and exclusion criteria. The observation group included 134 patients who received acupuncture at the Huiyin acupoint combined with Qingdu wash solution， while the control group consisted of 130 patients who did not receive any intervention. The treatment period lasted for three months， during which the short-term clinical efficacy and safety profile were evaluated. Results The HR-HPV clearance rates in the observation group at 3 months and 6 months were 61.9% and 65.7%， respectively， which were significantly higher than those in the control group （16.9% and 21.5%）， and the differences between the two groups were statistically significant （P < 0.001）. Following a three-month treatment regimen， the rate of HR-HPV positive-to-negative conversion in the observation group was significantly higher than that in the control group， with a statistically significant intergroup difference （P < 0.001）. The improvement in traditional Chinese medicine （TCM）-related symptoms was also significantly better in the observation group compared to the control group （P < 0.05）. During the follow-up period， no cases of recurrence were observed in the observation group， whereas the recurrence rate in the control group was 1.5%. Furthermore， no adverse reactions were reported in the observation group throughout the treatment period. Conclusion Acupuncture at the Huiyin point， when combined with Qingdu wash solution， can enhance the therapeutic outcomes of high-risk HPV infection and demonstrates a favorable safety profile.